Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties

Masayasu Komuro; Ryota Awa; Yuji Ito; Aritomo Yamaguchi; Kenichi Oyaizu; Makoto Yuasa

Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties

Masayasu Komuro^*, Ryota Awa, Yuji Ito, Aritomo Yamaguchi, Kenichi Oyaizu, Makoto Yuasa

^*Corresponding author for this work

Research output: Contribution to conference › Paper › peer-review

Abstract

In living body, oxygen (O₂) generates reactives oxygen species (ROS) such as superoxide anion radical (O₂^- ·). Living body has superoxide dismutase (SOD) enzyme for elimination of ROS. However, decrese of activity of SOD causes inflammation, cancer, and other deseases. In this study, we synthesized metalloporphyrins as anti-oxidant and anti-cancer drug. Novel alkylsulfonioporphyrin complexes were synthesized. It was revealed that they were effective as anti-oxidant and as anti-cancer agents, by stopped-flow method and cell viability tests, respectively.

Original language	English
Pages	2288
Number of pages	1
Publication status	Published - 2005
Externally published	Yes
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Conference

Conference	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

Alkylsulfonioporphyrin
Anti-cancer
Anti-oxidant
SOD model

ASJC Scopus subject areas

Engineering(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties",

abstract = "In living body, oxygen (O2) generates reactives oxygen species (ROS) such as superoxide anion radical (O2- ·). Living body has superoxide dismutase (SOD) enzyme for elimination of ROS. However, decrese of activity of SOD causes inflammation, cancer, and other deseases. In this study, we synthesized metalloporphyrins as anti-oxidant and anti-cancer drug. Novel alkylsulfonioporphyrin complexes were synthesized. It was revealed that they were effective as anti-oxidant and as anti-cancer agents, by stopped-flow method and cell viability tests, respectively.",

keywords = "Alkylsulfonioporphyrin, Anti-cancer, Anti-oxidant, SOD model",

author = "Masayasu Komuro and Ryota Awa and Yuji Ito and Aritomo Yamaguchi and Kenichi Oyaizu and Makoto Yuasa",

year = "2005",

language = "English",

pages = "2288",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

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TY - CONF

T1 - Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties

AU - Komuro, Masayasu

AU - Awa, Ryota

AU - Ito, Yuji

AU - Yamaguchi, Aritomo

AU - Oyaizu, Kenichi

AU - Yuasa, Makoto

PY - 2005

Y1 - 2005

N2 - In living body, oxygen (O2) generates reactives oxygen species (ROS) such as superoxide anion radical (O2- ·). Living body has superoxide dismutase (SOD) enzyme for elimination of ROS. However, decrese of activity of SOD causes inflammation, cancer, and other deseases. In this study, we synthesized metalloporphyrins as anti-oxidant and anti-cancer drug. Novel alkylsulfonioporphyrin complexes were synthesized. It was revealed that they were effective as anti-oxidant and as anti-cancer agents, by stopped-flow method and cell viability tests, respectively.

AB - In living body, oxygen (O2) generates reactives oxygen species (ROS) such as superoxide anion radical (O2- ·). Living body has superoxide dismutase (SOD) enzyme for elimination of ROS. However, decrese of activity of SOD causes inflammation, cancer, and other deseases. In this study, we synthesized metalloporphyrins as anti-oxidant and anti-cancer drug. Novel alkylsulfonioporphyrin complexes were synthesized. It was revealed that they were effective as anti-oxidant and as anti-cancer agents, by stopped-flow method and cell viability tests, respectively.

KW - Alkylsulfonioporphyrin

KW - Anti-cancer

KW - Anti-oxidant

KW - SOD model

UR - http://www.scopus.com/inward/record.url?scp=33645650016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645650016&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645650016

SP - 2288

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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