TY - JOUR
T1 - Synthesis of magnetic nanoparticles and their application to bioassays
AU - Osaka, Tetsuya
AU - Matsunaga, Tadashi
AU - Nakanishi, Takuya
AU - Arakaki, Atsushi
AU - Niwa, Daisuke
AU - Iida, Hironori
N1 - Funding Information:
Acknowledgements The authors acknowledge the financial support provided by Grants-in-Aid from COE Research (Molecular Nano-Engineering), Encouraging Development Strategic Research Centers Program, Special Coordination Funds for Promoting Science and Technology (Establishment of Consolidated Research Institute for Advanced Science and Medical Care), and the 21st Century COE Program (Center for Practical Nano-Chemistry) of the Ministry of Education, Culture, Sports, Science and Technology, Japan. The authors would like to acknowledge Dr. Y. Okinaka for valuable discussions.
PY - 2006/2
Y1 - 2006/2
N2 - Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
AB - Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
KW - Biomolecule detection
KW - Iron oxide
KW - Magnetic nanoparticle
KW - Patterned surface
KW - Surface modification
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U2 - 10.1007/s00216-005-0255-7
DO - 10.1007/s00216-005-0255-7
M3 - Review article
C2 - 16402174
AN - SCOPUS:32544439539
SN - 1618-2642
VL - 384
SP - 593
EP - 600
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
IS - 3
ER -