Synthesis of magnetic nanoparticles and their application to bioassays

Tetsuya Osaka*, Tadashi Matsunaga, Takuya Nakanishi, Atsushi Arakaki, Daisuke Niwa, Hironori Iida

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

178 Citations (Scopus)


Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.

Original languageEnglish
Pages (from-to)593-600
Number of pages8
JournalAnalytical and Bioanalytical Chemistry
Issue number3
Publication statusPublished - 2006 Feb


  • Biomolecule detection
  • Iron oxide
  • Magnetic nanoparticle
  • Patterned surface
  • Surface modification

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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