Synthesis of Natural Products and Pharmaceuticals via Catalytic C-H Functionalization

Junichiro Yamaguchi*, Kazuma Amaike, Kenichiro Itami

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)


The synthesis of natural products and pharmaceuticals, particularly those containing heterocyclic frameworks, can be dramatically simplified by using catalytic C-H functionalization. C-H functionalization has gathered significant interest from the organic synthesis community because it provides a new strategy to construct carbon-carbon and carbon-heteroatom bonds in highly functionalized, complex molecules without prefunctionalization. In this book chapter, methods in heterocycle substitution and synthesis using catalytic C-H functionalization are classified by heterocycle, with specific focus on the cutting-edge synthesis of natural products and pharmaceuticals.

Original languageEnglish
Title of host publicationTransition Metal-Catalyzed Heterocycle Synthesis via C-H Activation
Number of pages46
ISBN (Electronic)9783527691920
ISBN (Print)9783527338887
Publication statusPublished - 2016 Jan 12
Externally publishedYes


  • C-H functionalization
  • Heteroaromatics
  • Heterocycles
  • Natural products
  • Pharmaceuticals

ASJC Scopus subject areas

  • General Engineering
  • General Materials Science


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