Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O2 binding properties in lipid bilayers

Eishun Tsuchida; Hiroyuki Nishide; Etsuo Hasegawa; Yuzuru Chika; Masaki Fukuzumi; Teruyuki Komatsu

doi:10.1016/0162-0134(93)80061-D

Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O₂ binding properties in lipid bilayers

Eishun Tsuchida^*, Hiroyuki Nishide, Etsuo Hasegawa, Yuzuru Chika, Masaki Fukuzumi, Teruyuki Komatsu

^*Corresponding author for this work

Waseda Research Institute for Science and Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Synthesis and characterization of two amphiphilic tetraphenylporphinatoiron complexes having a glycerophosphocholine or an alkyl phosphoserine group are described. These porphinatoiron(II) complexes with 1-dodecyl-2-methyl-imidazole (L2MIm) were efficiently embedded in the bilayer of a phospholipid vesicle due to their high compatibility with lipids, similar to the heme substituted with four alkyl amphiphilic chains (lipid-heme). Oxygen transporting ability of the phospholipid vesicles embedded with hemes were similar to that of hemoglobin (Hb) in red blood cells.

Original language	English
Pages (from-to)	255-264
Number of pages	10
Journal	Journal of Inorganic Biochemistry
Volume	49
Issue number	4
DOIs	https://doi.org/10.1016/0162-0134(93)80061-D
Publication status	Published - 1993

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

Access to Document

10.1016/0162-0134(93)80061-D

Cite this

@article{b83f1ace15dc480ca8bc2614ab977363,

title = "Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O2 binding properties in lipid bilayers",

abstract = "Synthesis and characterization of two amphiphilic tetraphenylporphinatoiron complexes having a glycerophosphocholine or an alkyl phosphoserine group are described. These porphinatoiron(II) complexes with 1-dodecyl-2-methyl-imidazole (L2MIm) were efficiently embedded in the bilayer of a phospholipid vesicle due to their high compatibility with lipids, similar to the heme substituted with four alkyl amphiphilic chains (lipid-heme). Oxygen transporting ability of the phospholipid vesicles embedded with hemes were similar to that of hemoglobin (Hb) in red blood cells.",

author = "Eishun Tsuchida and Hiroyuki Nishide and Etsuo Hasegawa and Yuzuru Chika and Masaki Fukuzumi and Teruyuki Komatsu",

year = "1993",

doi = "10.1016/0162-0134(93)80061-D",

language = "English",

volume = "49",

pages = "255--264",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O2 binding properties in lipid bilayers

AU - Tsuchida, Eishun

AU - Nishide, Hiroyuki

AU - Hasegawa, Etsuo

AU - Chika, Yuzuru

AU - Fukuzumi, Masaki

AU - Komatsu, Teruyuki

PY - 1993

Y1 - 1993

N2 - Synthesis and characterization of two amphiphilic tetraphenylporphinatoiron complexes having a glycerophosphocholine or an alkyl phosphoserine group are described. These porphinatoiron(II) complexes with 1-dodecyl-2-methyl-imidazole (L2MIm) were efficiently embedded in the bilayer of a phospholipid vesicle due to their high compatibility with lipids, similar to the heme substituted with four alkyl amphiphilic chains (lipid-heme). Oxygen transporting ability of the phospholipid vesicles embedded with hemes were similar to that of hemoglobin (Hb) in red blood cells.

AB - Synthesis and characterization of two amphiphilic tetraphenylporphinatoiron complexes having a glycerophosphocholine or an alkyl phosphoserine group are described. These porphinatoiron(II) complexes with 1-dodecyl-2-methyl-imidazole (L2MIm) were efficiently embedded in the bilayer of a phospholipid vesicle due to their high compatibility with lipids, similar to the heme substituted with four alkyl amphiphilic chains (lipid-heme). Oxygen transporting ability of the phospholipid vesicles embedded with hemes were similar to that of hemoglobin (Hb) in red blood cells.

UR - http://www.scopus.com/inward/record.url?scp=0027403058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027403058&partnerID=8YFLogxK

U2 - 10.1016/0162-0134(93)80061-D

DO - 10.1016/0162-0134(93)80061-D

M3 - Article

C2 - 8478623

AN - SCOPUS:0027403058

SN - 0162-0134

VL - 49

SP - 255

EP - 264

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 4

ER -

Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O₂ binding properties in lipid bilayers

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this