TY - JOUR
T1 - Systemic estradiol administration to ovariectomized rats facilitates thermoregulatory behavior in a cold environment
AU - Uchida, Yuki
AU - Nagashima, Kei
AU - Yuri, Kazunari
N1 - Funding Information:
We are grateful to Dr. Yoji Osako (Kochi University) and Dr. Naoko Yamaguchi (Aichi Medical University) for their support of this research. The present study was partly supported by the Japan Society for the Promotion of Science; Grant-in-Aid for Young Scientists (Start-up), No. 24800047; Grant-in-Aid for Young Scientists (B), No. 26870417; Kochi University; Grant for Young Scientists (Start-up); and Hayashi Memorial Foundation for Female Natural Scientists.
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Rats place their tails underneath their bodies in the cold (tail-hiding behavior), which is a behavioral indicator of thermoregulation. The aim of the present study was to elucidate the effect of estradiol (E2) on tail-hiding behavior and neural activity assessed by immunohistochemistry. Ovariectomized rats were implanted with a silastic tube with or without E2 underneath the dorsal skin (E2(−) and E2(+) groups), and exposed to 27 °C, 16 °C, and 10 °C for 2 h with continuous body temperature (Tb), tail skin temperature (Ttail), and behavioral measurements. cFos immunoreactive (cFos-IR) cells in the insula, secondary somatosensory cortex, medial preoptic nucleus, parastrial nucleus, amygdala, and lateral parabrachial nucleus were counted. Tb and Ttail were not different between the E2(−) and E2(+) groups. At 16 °C, the duration and the onset of tail-hiding behavior in the E2(+) group were greater than that in the E2(−) group. The number of cFos-IR cells in the insula of the E2(−) group was greater than that of the E2(+) group in rats kept at 16 °C. E2 might modulate tail-hiding behavior of female rats at 16 °C, and the insula may be involved in the response.
AB - Rats place their tails underneath their bodies in the cold (tail-hiding behavior), which is a behavioral indicator of thermoregulation. The aim of the present study was to elucidate the effect of estradiol (E2) on tail-hiding behavior and neural activity assessed by immunohistochemistry. Ovariectomized rats were implanted with a silastic tube with or without E2 underneath the dorsal skin (E2(−) and E2(+) groups), and exposed to 27 °C, 16 °C, and 10 °C for 2 h with continuous body temperature (Tb), tail skin temperature (Ttail), and behavioral measurements. cFos immunoreactive (cFos-IR) cells in the insula, secondary somatosensory cortex, medial preoptic nucleus, parastrial nucleus, amygdala, and lateral parabrachial nucleus were counted. Tb and Ttail were not different between the E2(−) and E2(+) groups. At 16 °C, the duration and the onset of tail-hiding behavior in the E2(+) group were greater than that in the E2(−) group. The number of cFos-IR cells in the insula of the E2(−) group was greater than that of the E2(+) group in rats kept at 16 °C. E2 might modulate tail-hiding behavior of female rats at 16 °C, and the insula may be involved in the response.
KW - Body temperature
KW - Estradiol
KW - Tail skin temperature
KW - Tail-hiding behavior
UR - http://www.scopus.com/inward/record.url?scp=85021153976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021153976&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2017.06.009
DO - 10.1016/j.brainres.2017.06.009
M3 - Article
C2 - 28602745
AN - SCOPUS:85021153976
SN - 0006-8993
VL - 1670
SP - 125
EP - 134
JO - Brain Research
JF - Brain Research
ER -