Taking advantage of tailored electrostatics and complementary hydrogen bonding in the design of nanostructures for biomedical applications

Matthew T. Hunley; Afia S. Karikari; Matthew G. McKee; Brian D. Mather; John M. Layman; Ann R. Fornof; Timothy Edward Long

doi:10.1002/masy.200851001

Taking advantage of tailored electrostatics and complementary hydrogen bonding in the design of nanostructures for biomedical applications

Matthew T. Hunley, Afia S. Karikari, Matthew G. McKee, Brian D. Mather, John M. Layman, Ann R. Fornof, Timothy Edward Long

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Four-armed, star-shaped poly(D,L-lactide) (PDLLA) was synthesized and terminally-functionalized with either adenine or thymine complementary hydrogen bonding groups (PDLLA-A and PDLLA-T, respectively). The strong hydrogen bonding led to increased viscosity below the dissociation temperature of the hydrogen bonds. Rheology confirmed that these bonds were thermally reversible, with a sharp reduction in viscosity near 100°C. PDLLA, PDLLA-A, and PDLLA-T were melt electrospun with no significant change in fiber diameter (all between 3.6 and 4.0 μm). However, a blend of PDLLA-A and PDLLA-T formed fibers with an average diameter of 9.8 ± 2.0 μm, resulting from the hydrogen bond associations. Also, the phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine (POPE) was melt electrospun at 200°C and formed uniform fibers with average fiber diameter of 6.5 ± 2.0 μm.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Macromolecular Symposia
Volume	270
Issue number	1
DOIs	https://doi.org/10.1002/masy.200851001
Publication status	Published - 2008 Aug 1
Externally published	Yes

Keywords

Hydrogen bonding
Melt electrospinning
Phospholipids
Poly(D,L-lactide)
Thermoreversible

ASJC Scopus subject areas

Organic Chemistry
Materials Chemistry
Polymers and Plastics
Condensed Matter Physics

Access to Document

10.1002/masy.200851001

Cite this

@article{a4418a0171e54048b9793455bdaf5431,

title = "Taking advantage of tailored electrostatics and complementary hydrogen bonding in the design of nanostructures for biomedical applications",

abstract = "Four-armed, star-shaped poly(D,L-lactide) (PDLLA) was synthesized and terminally-functionalized with either adenine or thymine complementary hydrogen bonding groups (PDLLA-A and PDLLA-T, respectively). The strong hydrogen bonding led to increased viscosity below the dissociation temperature of the hydrogen bonds. Rheology confirmed that these bonds were thermally reversible, with a sharp reduction in viscosity near 100°C. PDLLA, PDLLA-A, and PDLLA-T were melt electrospun with no significant change in fiber diameter (all between 3.6 and 4.0 μm). However, a blend of PDLLA-A and PDLLA-T formed fibers with an average diameter of 9.8 ± 2.0 μm, resulting from the hydrogen bond associations. Also, the phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine (POPE) was melt electrospun at 200°C and formed uniform fibers with average fiber diameter of 6.5 ± 2.0 μm.",

keywords = "Hydrogen bonding, Melt electrospinning, Phospholipids, Poly(D,L-lactide), Thermoreversible",

author = "Hunley, {Matthew T.} and Karikari, {Afia S.} and McKee, {Matthew G.} and Mather, {Brian D.} and Layman, {John M.} and Fornof, {Ann R.} and Long, {Timothy Edward}",

year = "2008",

month = aug,

day = "1",

doi = "10.1002/masy.200851001",

language = "English",

volume = "270",

pages = "1--7",

journal = "Macromolecular Symposia",

issn = "1022-1360",

publisher = "Wiley-VCH Verlag",

number = "1",

}

TY - JOUR

T1 - Taking advantage of tailored electrostatics and complementary hydrogen bonding in the design of nanostructures for biomedical applications

AU - Hunley, Matthew T.

AU - Karikari, Afia S.

AU - McKee, Matthew G.

AU - Mather, Brian D.

AU - Layman, John M.

AU - Fornof, Ann R.

AU - Long, Timothy Edward

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Four-armed, star-shaped poly(D,L-lactide) (PDLLA) was synthesized and terminally-functionalized with either adenine or thymine complementary hydrogen bonding groups (PDLLA-A and PDLLA-T, respectively). The strong hydrogen bonding led to increased viscosity below the dissociation temperature of the hydrogen bonds. Rheology confirmed that these bonds were thermally reversible, with a sharp reduction in viscosity near 100°C. PDLLA, PDLLA-A, and PDLLA-T were melt electrospun with no significant change in fiber diameter (all between 3.6 and 4.0 μm). However, a blend of PDLLA-A and PDLLA-T formed fibers with an average diameter of 9.8 ± 2.0 μm, resulting from the hydrogen bond associations. Also, the phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine (POPE) was melt electrospun at 200°C and formed uniform fibers with average fiber diameter of 6.5 ± 2.0 μm.

AB - Four-armed, star-shaped poly(D,L-lactide) (PDLLA) was synthesized and terminally-functionalized with either adenine or thymine complementary hydrogen bonding groups (PDLLA-A and PDLLA-T, respectively). The strong hydrogen bonding led to increased viscosity below the dissociation temperature of the hydrogen bonds. Rheology confirmed that these bonds were thermally reversible, with a sharp reduction in viscosity near 100°C. PDLLA, PDLLA-A, and PDLLA-T were melt electrospun with no significant change in fiber diameter (all between 3.6 and 4.0 μm). However, a blend of PDLLA-A and PDLLA-T formed fibers with an average diameter of 9.8 ± 2.0 μm, resulting from the hydrogen bond associations. Also, the phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine (POPE) was melt electrospun at 200°C and formed uniform fibers with average fiber diameter of 6.5 ± 2.0 μm.

KW - Hydrogen bonding

KW - Melt electrospinning

KW - Phospholipids

KW - Poly(D,L-lactide)

KW - Thermoreversible

UR - http://www.scopus.com/inward/record.url?scp=55049103314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55049103314&partnerID=8YFLogxK

U2 - 10.1002/masy.200851001

DO - 10.1002/masy.200851001

M3 - Article

AN - SCOPUS:55049103314

SN - 1022-1360

VL - 270

SP - 1

EP - 7

JO - Macromolecular Symposia

JF - Macromolecular Symposia

IS - 1

ER -

Taking advantage of tailored electrostatics and complementary hydrogen bonding in the design of nanostructures for biomedical applications

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this