Tb 3+-enhanced potentiometric detection of single nucleotide polymorphism by field effect transistors

Jinping Wang; Kenya Ito; Takuya Nakanishi; Shigeki Kuroiwa; Tetsuya Osaka

doi:10.1246/cl.2009.376

Tb ³⁺-enhanced potentiometric detection of single nucleotide polymorphism by field effect transistors

Jinping Wang, Kenya Ito, Takuya Nakanishi, Shigeki Kuroiwa, Tetsuya Osaka^*

^*Corresponding author for this work

Comprehensive Research Organization

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The use of Tb ³⁺ as a center ion and media to introduce more exogenously negative charges onto double-stranded DNA (dsDNA), can greatly enhance potentiometric signals produced by the shift of gate voltage of field effect transisitor (FET). Furthermore, different affinities of Tb ³⁺ to normal and mismatched dsDNAs amplified the signal difference between their detections, which can improve the discrimination of single nucleotide polymorphism.

Original language	English
Pages (from-to)	376-377
Number of pages	2
Journal	Chemistry Letters
Volume	38
Issue number	4
DOIs	https://doi.org/10.1246/cl.2009.376
Publication status	Published - 2009

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2009.376

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abstract = "The use of Tb 3+ as a center ion and media to introduce more exogenously negative charges onto double-stranded DNA (dsDNA), can greatly enhance potentiometric signals produced by the shift of gate voltage of field effect transisitor (FET). Furthermore, different affinities of Tb 3+ to normal and mismatched dsDNAs amplified the signal difference between their detections, which can improve the discrimination of single nucleotide polymorphism.",

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AU - Nakanishi, Takuya

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AU - Osaka, Tetsuya

PY - 2009

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Tb ³⁺-enhanced potentiometric detection of single nucleotide polymorphism by field effect transistors

Abstract

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