The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs

Shigenobu Shibata*, Yu Tahara, Akiko Hirao

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

73 Citations (Scopus)


Daily restricted feeding entrains the circadian rhythm of mouse clock gene expression in the central nervous system, excluding the suprachiasmatic nucleus (SCN), as well as in the peripheral tissues such as the liver, lung, and heart. In addition to entrainment of the clock genes, daily restricted feeding induces a locomotor activity increase 2-3. h before the restricted feeding time initiates. The increase in activity is called the food-anticipatory activity (FAA). In addition to FAA, daily restricted feeding can also entrain peripheral circadian clocks in other organs such as liver, lung, and heart. This type of oscillator is called the food-entrainable peripheral oscillator (FEPO). At present, the mechanisms for restricted feeding-induced entrainment of locomotor activity (FAA) and/or peripheral clock (FEPO) are still unknown. In this review, we describe the role of the central nervous system and peripheral tissues in FAA performance and also in the entrainment of clock gene expression. In addition, the mechanism for entrainment of circadian oscillators by the abuse of drugs, such as methamphetamine, is discussed.

Original languageEnglish
Pages (from-to)918-927
Number of pages10
JournalAdvanced Drug Delivery Reviews
Issue number9-10
Publication statusPublished - 2010 Jul


  • Clock gene
  • Drug of abuse
  • Entrainment
  • Food anticipation
  • Hypothalamus
  • Liver
  • Nutrition
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Pharmaceutical Science


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