TY - JOUR
T1 - The association between homocysteine, arterial stiffness and executive function middle-age and older women
AU - Shindo-Hamasaki, Ai
AU - Akazawa, Nobuhiko
AU - Momma, Reiko
AU - Maeda, Seiji
N1 - Funding Information:
This study was supported by Japanese Physical Therapy Association Research Grants in 2017 (JPTA H29-B11).
Publisher Copyright:
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V. This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
PY - 2021/3
Y1 - 2021/3
N2 - Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains unclear. This study aimed to investigate the relationship between executive function, arterial stiffness, and plasma homocysteine in 82 middle-aged and older women. The Stroop interference time, Brachial-ankle Pulse Wave Velocity (baPWV), and plasma homocysteine concentration were collected. The correlation analyses revealed that the Stroop interference time was significantly correlated with plasma homocysteine (r = 0.40, p < 0.001) and baPWV (r = 0.38, p = 0.001). In addition, plasma homocysteine levels were significantly correlated with baPWV (r = 0.48, p < 0.001). In the mediated analyses, the plasma homocysteine level directly (b = 0.24; p = 0.037) and indirectly (b = 0.12, 95% confidence interval [0.007, 0.238]) affected the Stroop interference time. These results suggest that higher plasma homocysteine levels are associated with a decline in executive function mediated by higher artery stiffness in middle-aged and older women.
AB - Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains unclear. This study aimed to investigate the relationship between executive function, arterial stiffness, and plasma homocysteine in 82 middle-aged and older women. The Stroop interference time, Brachial-ankle Pulse Wave Velocity (baPWV), and plasma homocysteine concentration were collected. The correlation analyses revealed that the Stroop interference time was significantly correlated with plasma homocysteine (r = 0.40, p < 0.001) and baPWV (r = 0.38, p = 0.001). In addition, plasma homocysteine levels were significantly correlated with baPWV (r = 0.48, p < 0.001). In the mediated analyses, the plasma homocysteine level directly (b = 0.24; p = 0.037) and indirectly (b = 0.12, 95% confidence interval [0.007, 0.238]) affected the Stroop interference time. These results suggest that higher plasma homocysteine levels are associated with a decline in executive function mediated by higher artery stiffness in middle-aged and older women.
KW - Arterial stiffness
KW - Executive function
KW - Plasma homocysteine
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U2 - 10.2991/ARTRES.K.201102.003
DO - 10.2991/ARTRES.K.201102.003
M3 - Article
AN - SCOPUS:85104435662
SN - 1872-9312
VL - 27
SP - 32
EP - 37
JO - Artery Research
JF - Artery Research
IS - 1
ER -