TY - JOUR
T1 - The asymmetric total synthesis of (+)-cytotrienin A, an ansamycin-type anticancer drug
AU - Hayashi, Yujiro
AU - Shoji, Mitsuru
AU - Ishikawa, Hayato
AU - Yamaguchi, Junichiro
AU - Tamura, Tomohiro
AU - Imai, Hiroki
AU - Nishigaya, Yosuke
AU - Takabe, Kenichi
AU - Kakeya, Hideaki
AU - Osada, Hiroyuki
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/8/18
Y1 - 2008/8/18
N2 - (Chemical Equation Presented) A star-studded lineup: (+)-Cytotrienin A was the target of an asymmetric total synthesis featuring an enantioselective aldol reaction, α-aminoxylation, deoxygenation, and a ring-closing metathesis to form the 21-membered macrolactam. This first total synthesis confirms the relative and absolute confguration of the molecule.
AB - (Chemical Equation Presented) A star-studded lineup: (+)-Cytotrienin A was the target of an asymmetric total synthesis featuring an enantioselective aldol reaction, α-aminoxylation, deoxygenation, and a ring-closing metathesis to form the 21-membered macrolactam. This first total synthesis confirms the relative and absolute confguration of the molecule.
KW - Aldol reaction
KW - Asymmetric synthesis
KW - Organocatalysis
KW - Ring-closing metathesis
KW - Total synthesis
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U2 - 10.1002/anie.200802079
DO - 10.1002/anie.200802079
M3 - Article
C2 - 18646025
AN - SCOPUS:52449116434
SN - 1433-7851
VL - 47
SP - 6657
EP - 6660
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 35
ER -