TY - JOUR
T1 - The caudal periaqueductal gray participates in the activation of brown adipose tissue in rats
AU - Chen, Xiao Ming
AU - Nishi, Maiko
AU - Taniguchi, Aki
AU - Nagashima, Kei
AU - Shibata, Masaaki
AU - Kanosue, Kazuyuki
N1 - Funding Information:
We thank Dr Robin McAllen for his critical reading of and comments on this manuscript. This study was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (Grants No. 04454143, No. 09470016, and No. 12307001).
PY - 2002/10/4
Y1 - 2002/10/4
N2 - To investigate the involvement of the periaqueductal gray (PAG) in the control of non-shivering thermogenesis, we tested the effects of electrical or chemical stimulation of the PAG on thermogenesis of brown adipose tissue (BAT) in urethane anesthetized rats. Electrical stimulation (0.1 mA, 33 Hz, 0.5 ms) or application of D,L-homocysteic acid (0.5 mM, 0.3 μl) into the lateral region of the caudal PAG (cPAG) elicited BAT thermogenesis, measured as a rise in the local temperature of interscapular BAT. These results suggest that neurons in the cPAG send excitatory efferent signals for BAT thermogenesis.
AB - To investigate the involvement of the periaqueductal gray (PAG) in the control of non-shivering thermogenesis, we tested the effects of electrical or chemical stimulation of the PAG on thermogenesis of brown adipose tissue (BAT) in urethane anesthetized rats. Electrical stimulation (0.1 mA, 33 Hz, 0.5 ms) or application of D,L-homocysteic acid (0.5 mM, 0.3 μl) into the lateral region of the caudal PAG (cPAG) elicited BAT thermogenesis, measured as a rise in the local temperature of interscapular BAT. These results suggest that neurons in the cPAG send excitatory efferent signals for BAT thermogenesis.
KW - Non-shivering thermogenesis
KW - Periaqueductal gray
KW - Thermoregulation
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U2 - 10.1016/S0304-3940(02)00757-7
DO - 10.1016/S0304-3940(02)00757-7
M3 - Article
C2 - 12359313
AN - SCOPUS:0037020487
SN - 0304-3940
VL - 331
SP - 17
EP - 20
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -