@article{e0a23a201b9549b0b9858d16cc758823,
title = "The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice",
abstract = "To clarify the effects of a dipeptidyl peptidase-4 (DPP-4) inhibitor on whole-body energy metabolism, we treated mice fed a high-fat diet (HFD) with teneligliptin, a clinically available DPP-4 inhibitor. Teneligliptin significantly prevented HFD-induced obesity and obesity-associated metabolic disorders. It also increased oxygen consumption rate and upregulated uncoupling protein 1 (UCP1) expression in both brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT), suggesting that it enhances BAT function. Soluble DPP-4 inhibited β-adrenoreceptor-stimulated UCP1 expression in primary adipocytes, and this inhibition was prevented in the presence of teneligliptin, or an extracellular signal-related kinase inhibitor. These results indicate that soluble DPP-4 inhibits β-adrenoreceptor-stimulated UCP1 induction and that chronic DPP-4 inhibitor treatment may prevent obesity through the activation of BAT function.",
keywords = "UCP1, beige adipocytes, brown adipocytes, dipeptidyl peptidase-4, obesity, teneligliptin",
author = "Kenichiro Takeda and Honami Sawazaki and Haruya Takahashi and Yeh, {Yu Sheng} and Jheng, {Huei Fen} and Wataru Nomura and Takeshi Ara and Nobuyuki Takahashi and Shigeto Seno and Naoki Osato and Hideo Matsuda and Teruo Kawada and Tsuyoshi Goto",
note = "Funding Information: The authors thank M. Komori and S. Shinotoh (Kyoto University) for their technical and secretarial support, respectively. We are very grateful to Mitsubishi Tanabe Pharma Corporation for their kind provision of teneligliptin to this study. This study was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (16K07734, 16H02551, 16K12525 and 15K00403). This research used computational resources through the HPCI System Research Project (Project ID: hp170265). Funding Information: The authors thank M. Komori and S. Shinotoh (Kyoto University) for their technical and secretarial support, respectively. We are very grateful to Mit-subishi Tanabe Pharma Corporation for their kind provision of teneligliptin to this study. This study was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (16K07734, 16H02551, 16K12525 and 15K00403). This research used computational resources through the HPCI System Research Project (Project ID: hp170265). Publisher Copyright: {\textcopyright} 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.",
year = "2018",
month = nov,
doi = "10.1002/2211-5463.12498",
language = "English",
volume = "8",
pages = "1782--1793",
journal = "FEBS Open Bio",
issn = "2211-5463",
publisher = "Elsevier BV",
number = "11",
}
