The effect of food intake on pharmacokinetics of lansoprazole OD tablet

Yasuhiro Fujiwara; Hirotoshi Okazaki; Akira Higashimori; Naoko Sugita; Masako Tanaka; Taishi Sakai; Masanori Kobayashi; Masaki Shindo; Hirohisa Machida; Tetsuya Tanigawa; Hirokazu Yamagami; Kenji Watanabe; Toshio Watanabe; Kazunari Tominaga; Tetsuo Arakawa

The effect of food intake on pharmacokinetics of lansoprazole OD tablet

Yasuhiro Fujiwara^*, Hirotoshi Okazaki, Akira Higashimori, Naoko Sugita, Masako Tanaka, Taishi Sakai, Masanori Kobayashi, Masaki Shindo, Hirohisa Machida, Tetsuya Tanigawa, Hirokazu Yamagami, Kenji Watanabe, Toshio Watanabe, Kazunari Tominaga, Tetsuo Arakawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background and Objective: Insufficient absorption of proton pump inhibitor (PPI) might be a treatment refractory factor, however, limited evidences were reported on the effect of pharmacokinetic parameter of PPI when taking the drug after food intake. The aim of this study was to compare the pharmacokinetic parameter of lansoprazole orally dispersing (LPZ-OD) tablet between conditions of taking the drug after food intake and under fasting conditions. Methods: Nine healthy male volunteers took LPZ-OD (Takepron® OD) tablet 30 mg either 15 minutes after breakfast or under fasting conditions in a cross-over fashion. The wash-out period of each term was 7 days at least. Blood samples were taken for measurement of pharmacokinetic parameter of LPZ. Results: The AUC _0-inf, C _max, and t _max in the drug administration after food intake were significantly decreased than that of fasting conditions. The respective AUC _0-inf was 4512±1958 ng·h/mL and 3083±1688 ng·h/mL (p<0.05), C _max was 1275±528 ng/mL and 624±307 ng/mL (p<0.05), and t _max was 2.0±0.8 h and 3.3±1.0 h (p<0.05). No significant difference in t _1/2 was observed. Conclusions: This study suggested food intake may affect pharmacokinetic parameters (AUC _0-inf, C _max, and t _max) of LPZ-OD tablet.

Original language	English
Pages (from-to)	961-966
Number of pages	6
Journal	Japanese Pharmacology and Therapeutics
Volume	39
Issue number	11
Publication status	Published - 2011 Nov 20
Externally published	Yes

Keywords

Food intake
Lansoprazole
Pharmacokinetics
Resistance

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

Cite this

@article{4750c6a8f00e4860ade7e867d35ca415,

title = "The effect of food intake on pharmacokinetics of lansoprazole OD tablet",

abstract = "Background and Objective: Insufficient absorption of proton pump inhibitor (PPI) might be a treatment refractory factor, however, limited evidences were reported on the effect of pharmacokinetic parameter of PPI when taking the drug after food intake. The aim of this study was to compare the pharmacokinetic parameter of lansoprazole orally dispersing (LPZ-OD) tablet between conditions of taking the drug after food intake and under fasting conditions. Methods: Nine healthy male volunteers took LPZ-OD (Takepron{\textregistered} OD) tablet 30 mg either 15 minutes after breakfast or under fasting conditions in a cross-over fashion. The wash-out period of each term was 7 days at least. Blood samples were taken for measurement of pharmacokinetic parameter of LPZ. Results: The AUC 0-inf, C max, and t max in the drug administration after food intake were significantly decreased than that of fasting conditions. The respective AUC 0-inf was 4512±1958 ng·h/mL and 3083±1688 ng·h/mL (p<0.05), C max was 1275±528 ng/mL and 624±307 ng/mL (p<0.05), and t max was 2.0±0.8 h and 3.3±1.0 h (p<0.05). No significant difference in t 1/2 was observed. Conclusions: This study suggested food intake may affect pharmacokinetic parameters (AUC 0-inf, C max, and t max) of LPZ-OD tablet.",

keywords = "Food intake, Lansoprazole, Pharmacokinetics, Resistance",

author = "Yasuhiro Fujiwara and Hirotoshi Okazaki and Akira Higashimori and Naoko Sugita and Masako Tanaka and Taishi Sakai and Masanori Kobayashi and Masaki Shindo and Hirohisa Machida and Tetsuya Tanigawa and Hirokazu Yamagami and Kenji Watanabe and Toshio Watanabe and Kazunari Tominaga and Tetsuo Arakawa",

year = "2011",

month = nov,

day = "20",

language = "English",

volume = "39",

pages = "961--966",

journal = "Japanese Pharmacology and Therapeutics",

issn = "0386-3603",

publisher = "Life Science Publishing Co. Ltd",

number = "11",

}

TY - JOUR

T1 - The effect of food intake on pharmacokinetics of lansoprazole OD tablet

AU - Fujiwara, Yasuhiro

AU - Okazaki, Hirotoshi

AU - Higashimori, Akira

AU - Sugita, Naoko

AU - Tanaka, Masako

AU - Sakai, Taishi

AU - Kobayashi, Masanori

AU - Shindo, Masaki

AU - Machida, Hirohisa

AU - Tanigawa, Tetsuya

AU - Yamagami, Hirokazu

AU - Watanabe, Kenji

AU - Watanabe, Toshio

AU - Tominaga, Kazunari

AU - Arakawa, Tetsuo

PY - 2011/11/20

Y1 - 2011/11/20

N2 - Background and Objective: Insufficient absorption of proton pump inhibitor (PPI) might be a treatment refractory factor, however, limited evidences were reported on the effect of pharmacokinetic parameter of PPI when taking the drug after food intake. The aim of this study was to compare the pharmacokinetic parameter of lansoprazole orally dispersing (LPZ-OD) tablet between conditions of taking the drug after food intake and under fasting conditions. Methods: Nine healthy male volunteers took LPZ-OD (Takepron® OD) tablet 30 mg either 15 minutes after breakfast or under fasting conditions in a cross-over fashion. The wash-out period of each term was 7 days at least. Blood samples were taken for measurement of pharmacokinetic parameter of LPZ. Results: The AUC 0-inf, C max, and t max in the drug administration after food intake were significantly decreased than that of fasting conditions. The respective AUC 0-inf was 4512±1958 ng·h/mL and 3083±1688 ng·h/mL (p<0.05), C max was 1275±528 ng/mL and 624±307 ng/mL (p<0.05), and t max was 2.0±0.8 h and 3.3±1.0 h (p<0.05). No significant difference in t 1/2 was observed. Conclusions: This study suggested food intake may affect pharmacokinetic parameters (AUC 0-inf, C max, and t max) of LPZ-OD tablet.

AB - Background and Objective: Insufficient absorption of proton pump inhibitor (PPI) might be a treatment refractory factor, however, limited evidences were reported on the effect of pharmacokinetic parameter of PPI when taking the drug after food intake. The aim of this study was to compare the pharmacokinetic parameter of lansoprazole orally dispersing (LPZ-OD) tablet between conditions of taking the drug after food intake and under fasting conditions. Methods: Nine healthy male volunteers took LPZ-OD (Takepron® OD) tablet 30 mg either 15 minutes after breakfast or under fasting conditions in a cross-over fashion. The wash-out period of each term was 7 days at least. Blood samples were taken for measurement of pharmacokinetic parameter of LPZ. Results: The AUC 0-inf, C max, and t max in the drug administration after food intake were significantly decreased than that of fasting conditions. The respective AUC 0-inf was 4512±1958 ng·h/mL and 3083±1688 ng·h/mL (p<0.05), C max was 1275±528 ng/mL and 624±307 ng/mL (p<0.05), and t max was 2.0±0.8 h and 3.3±1.0 h (p<0.05). No significant difference in t 1/2 was observed. Conclusions: This study suggested food intake may affect pharmacokinetic parameters (AUC 0-inf, C max, and t max) of LPZ-OD tablet.

KW - Food intake

KW - Lansoprazole

KW - Pharmacokinetics

KW - Resistance

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M3 - Article

AN - SCOPUS:84455194052

SN - 0386-3603

VL - 39

SP - 961

EP - 966

JO - Japanese Pharmacology and Therapeutics

JF - Japanese Pharmacology and Therapeutics

IS - 11

ER -

The effect of food intake on pharmacokinetics of lansoprazole OD tablet

Abstract

Keywords

ASJC Scopus subject areas

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