TY - JOUR
T1 - The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients
T2 - A Randomized Clinical Trial
AU - Majidi, Nazanin
AU - Rabbani, Faezeh
AU - Gholami, Somayeh
AU - Gholamalizadeh, Maryam
AU - BourBour, Fatemeh
AU - Rastgoo, Samira
AU - Hajipour, Azadeh
AU - Shadnoosh, Mahdi
AU - Akbari, Mohammad Esmail
AU - Bahar, Bojlul
AU - Ashoori, Narjes
AU - Alizadeh, Atiyeh
AU - Samipoor, Forough
AU - Moslem, Alireza
AU - Doaei, Saeid
AU - Suzuki, Katsuhiko
N1 - Funding Information:
The funding for this study was provided by Sabzevar University of Medical Sciences, Sabzevar, Iran (code 99213).
Publisher Copyright:
Copyright © 2021 Majidi, Rabbani, Gholami, Gholamalizadeh, BourBour, Rastgoo, Hajipour, Shadnoosh, Akbari, Bahar, Ashoori, Alizadeh, Samipoor, Moslem, Doaei and Suzuki.
PY - 2021/12/15
Y1 - 2021/12/15
N2 - Introduction: Vitamin C has been reported to have beneficial effects on patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of vitamin C supplementation on pathological parameters and survival duration of critically ill patients with COVID-19. Methods: This clinical trial was conducted on 120 hospitalized critically ill patients infected with COVID-19. The intervention group (n = 31) received one capsule of 500 mg of vitamin C daily for 14 days. The control group (n = 69) received the same nutrition except for vitamin C supplements. Measurement of pathological and biochemical parameters was performed at baseline and after 2 weeks of the intervention. Results: Following 2 weeks of vitamin C supplementation, the level of serum K was significantly lower in the patients compared with the control group (3.93 vs. 4.21 mEq/L, p < 0.01). Vitamin C supplementation resulted in a higher mean survival duration compared with that of the control group (8 vs. 4 days, p < 0.01). There was a linear association between the number of days of vitamin C intake and survival duration (B = 1.66, p < 0.001). The vitamin C supplementation had no effect on blood glucose, mean arterial pressure, arterial blood gas (ABG) parameters, Glasgow Coma Scale (GCS), kidney function, cell blood count (CBC), hemoglobin (Hb), platelet (Plt), partial thromboplastin time (PTT), albumin, hematocrit (Hct), and other serum electrolytes including sodium (Na), calcium, and phosphorus (P). Conclusion: The present study demonstrated the potential of vitamin C supplementation in enhancing the survival duration of critically ill patients with COVID-19. Clinical Trial Registration: https://www.irct.ir/trial/55074, identifier IRCT20151226025699N5.
AB - Introduction: Vitamin C has been reported to have beneficial effects on patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of vitamin C supplementation on pathological parameters and survival duration of critically ill patients with COVID-19. Methods: This clinical trial was conducted on 120 hospitalized critically ill patients infected with COVID-19. The intervention group (n = 31) received one capsule of 500 mg of vitamin C daily for 14 days. The control group (n = 69) received the same nutrition except for vitamin C supplements. Measurement of pathological and biochemical parameters was performed at baseline and after 2 weeks of the intervention. Results: Following 2 weeks of vitamin C supplementation, the level of serum K was significantly lower in the patients compared with the control group (3.93 vs. 4.21 mEq/L, p < 0.01). Vitamin C supplementation resulted in a higher mean survival duration compared with that of the control group (8 vs. 4 days, p < 0.01). There was a linear association between the number of days of vitamin C intake and survival duration (B = 1.66, p < 0.001). The vitamin C supplementation had no effect on blood glucose, mean arterial pressure, arterial blood gas (ABG) parameters, Glasgow Coma Scale (GCS), kidney function, cell blood count (CBC), hemoglobin (Hb), platelet (Plt), partial thromboplastin time (PTT), albumin, hematocrit (Hct), and other serum electrolytes including sodium (Na), calcium, and phosphorus (P). Conclusion: The present study demonstrated the potential of vitamin C supplementation in enhancing the survival duration of critically ill patients with COVID-19. Clinical Trial Registration: https://www.irct.ir/trial/55074, identifier IRCT20151226025699N5.
KW - COVID-19
KW - critically ill patients
KW - potassium
KW - supplementation
KW - survival
KW - vitamin C
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U2 - 10.3389/fimmu.2021.717816
DO - 10.3389/fimmu.2021.717816
M3 - Article
C2 - 34975830
AN - SCOPUS:85121974011
SN - 1664-3224
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 717816
ER -