TY - JOUR
T1 - The effects of beta-hydroxy-beta-methylbutyrate-free acidsupplementation and resistance training on oxidative stress markers
T2 - A randomized,double-blind, placebo-controlled study
AU - Arazi, Hamid
AU - Asadi, Abbas
AU - Suzuki, Katsuhiko
N1 - Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/6/11
Y1 - 2018/6/11
N2 - The aim of this study was to investigate the effects of 6-week beta-hydroxy-beta methylbutyrate-free acid (HMB-FA) supplementation on oxidative stress and biochemical variablesin responses to resistance training. Sixteen healthy young males participated in this study and were randomly assigned to a HMB-FA supplementation group (n = 8) or a placebo supplementation group (n = 8). The resistance training program was applied for 6 weeks with two sessions per week. Blood samples were collected before and after training, and 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyl (PC), and biochemical variables, such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and the numbers of total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were analyzed.Following intervention, both the HMB-FA and placebo supplementation groups showed significant decreases in MDA (effect size [ES]; 0.39, 0.33) and PC (ES; 1.37,1.41), respectively. However,8-OHdG did not change after 6 weeks of training in any of the groups. In addition, both groups showed similar training effects on biochemical variables after 6 weeks of intervention. It was concluded that HMB-FA supplementation during resistance training did not add further adaptive changes related to oxidative stress markers.
AB - The aim of this study was to investigate the effects of 6-week beta-hydroxy-beta methylbutyrate-free acid (HMB-FA) supplementation on oxidative stress and biochemical variablesin responses to resistance training. Sixteen healthy young males participated in this study and were randomly assigned to a HMB-FA supplementation group (n = 8) or a placebo supplementation group (n = 8). The resistance training program was applied for 6 weeks with two sessions per week. Blood samples were collected before and after training, and 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyl (PC), and biochemical variables, such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and the numbers of total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were analyzed.Following intervention, both the HMB-FA and placebo supplementation groups showed significant decreases in MDA (effect size [ES]; 0.39, 0.33) and PC (ES; 1.37,1.41), respectively. However,8-OHdG did not change after 6 weeks of training in any of the groups. In addition, both groups showed similar training effects on biochemical variables after 6 weeks of intervention. It was concluded that HMB-FA supplementation during resistance training did not add further adaptive changes related to oxidative stress markers.
KW - Free radicals
KW - Leucine
KW - Oxidative stress
KW - Strength training
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U2 - 10.3390/antiox7060076
DO - 10.3390/antiox7060076
M3 - Article
AN - SCOPUS:85049537527
SN - 2076-3921
VL - 7
JO - Antioxidants
JF - Antioxidants
IS - 6
M1 - 76
ER -