The effects of Lactobacillus gasseri OLL2809 intake on oral immune function in college rugby athletes

Yukichi Hanaoka, Kazuhiro Shimizu, Kosuke Washiya, Akira Tamura, Masahiro Takemura, Takuo Furukawa, Toshikazu Miyamoto, Koichi Watanabe, Takao Akama

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The purpose of this study was to investigate the effects of Lactobacillus gasseri OLL2809 (MG2809) intake on salivary secretory immunoglobulin A (SIgA) secretion and incidence of upper-respiratory tract infection (URTI) symptoms among college rugby athletes. Sixty-seven subjects were assigned to a MG2809 group (n = 33) or a placebo group (n = 34) using a double-blind procedure. Each subject took MG2809 or placebo tablets for 9 weeks. Resting saliva samples were collected before (0 week) and after 2, 4, 6, 8, and 9 weeks of the MG2809 intakes. A log of URTI symptoms was kept every day during the study period. Our results showed that salivary SIgA level was significantly increased at 6 weeks in the MG2809 group (p < 0.05), although the placebo group did not show significant change. The duration of URTI symptoms episode in the MG2809 group was significantly shorter than that in the placebo (p < 0.05). These results suggest that regular intake of MG2809 may enhance oral immune function mediated by SIgA and reduce the risk of URTI in athletes.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
Journaljapanese journal of physical fitness and sports medicine
Issue number3
Publication statusPublished - 2015


  • Athlete
  • Exercise
  • Lactic acid bacteria
  • MG2809
  • Secretory immunoglobulin A

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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