The effects of resveratrol on tendon healing of diabetic rats

Kayhan Zeytin*, Nesibe Sinem Çiloǧlu, Filiz Ateş, Fugen Vardar Aker, Feriha Ercan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Objective: The aim of this study was to determine the effects of resveratrol on the tendon healing process of streptozotocin-induced diabetic rats. Methods: The study included 16 male Sprague-Dawley rats. Streptozotocin was administered to induce diabetes and bilateral tenorrhaphy of the Achilles tendons was performed. Intraperitoneal resveratrol was injected in the experimental group (n=8) and saline in the control group (n=8) during the postoperative period. Rats were sacrificed at the 14th day. Right side tendons were evaluated biomechanically and left side tendons histologically. Results: Difference in mean tendon tensile strength was not statistically significant between groups (p>0.05). Histologic evaluations of the repair zones showed greater configuration of the newly synthesized collagen in the experimental group. The ratio of the newly synthesized collagen area to the healing region area was significantly higher in the experimental group then the control group (p

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalActa Orthopaedica et Traumatologica Turcica
Issue number3
Publication statusPublished - 2014
Externally publishedYes


  • Diabetic
  • Resveratrol
  • Tendon healing
  • Tensile strength

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery
  • Medicine(all)


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