@article{9877c358985f4df39f594249d9e36b7b,
title = "The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic",
abstract = "The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael-Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.",
keywords = "Glycosylation, Lactonamycin, Michael-Dieckmann type annulation, Thioester, Total synthesis",
author = "Kuniaki Tatsuta and Hiroaki Tanaka and Hitomi Tsukagoshi and Takafumi Kashima and Seijiro Hosokawa",
note = "Funding Information: Special thanks to Dr. Yoshikazu Takahashi in Microbial Chemistry Research Center for providing natural lactonamycin. The authors thank Mr. Kunitoshi Takeda and Ms. Utako Furukawa for preliminary studies. This work was financially supported by the Consolidated Research Institute for Advanced Science and Medical Care, the Global COE program {\textquoteleft}Center for Practical Chemical Wisdom{\textquoteright}, and the Scientific Research on Priority Area {\textquoteleft}Creation of Biologically Functional Molecules{\textquoteright} from the Ministry of Education, Culture, Sports, Science and Technology. ",
year = "2010",
month = oct,
day = "20",
doi = "10.1016/j.tetlet.2010.08.035",
language = "English",
volume = "51",
pages = "5546--5549",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd",
number = "42",
}