The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

Manami Oya; Tetsuya Kitaguchi; Ramona Pais; Frank Reimann; Fiona Gribble; Takashi Tsuboi

doi:10.1074/jbc.M112.402677

The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

Manami Oya, Tetsuya Kitaguchi, Ramona Pais, Frank Reimann, Fiona Gribble, Takashi Tsuboi^*

^*Corresponding author for this work

Organization for University Research Initiatives

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120 Citations (Scopus)

Abstract

Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.

Original language	English
Pages (from-to)	4513-4521
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.402677
Publication status	Published - 2013 Feb 15

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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title = "The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells",

abstract = "Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.",

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T1 - The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

AU - Oya, Manami

AU - Kitaguchi, Tetsuya

AU - Pais, Ramona

AU - Reimann, Frank

AU - Gribble, Fiona

AU - Tsuboi, Takashi

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.

AB - Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.

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The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

Abstract

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