The life-extending effect of dietary restriction requires Foxo3 in mice

Isao Shimokawa; Toshimitsu Komatsu; Nobutaka Hayashi; Sang Eun Kim; Takuya Kawata; Seongjoon Park; Hiroko Hayashi; Haruyoshi Yamaza; Takuya Chiba; Ryoichi Mori

doi:10.1111/ACEL.12340

The life-extending effect of dietary restriction requires Foxo3 in mice

Isao Shimokawa^*, Toshimitsu Komatsu, Nobutaka Hayashi, Sang Eun Kim, Takuya Kawata, Seongjoon Park, Hiroko Hayashi, Haruyoshi Yamaza, Takuya Chiba, Ryoichi Mori

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (^+/–) and homozygous (^–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3^+/– or Foxo3^–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3^+/–, and Foxo3^–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3^+/– mice contrast with those in Foxo1^+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.

Original language	English
Pages (from-to)	707-709
Number of pages	3
Journal	Aging cell
Volume	14
Issue number	4
DOIs	https://doi.org/10.1111/ACEL.12340
Publication status	Published - 2015 Aug
Externally published	Yes

Keywords

Foxo
cancer
dietary restriction
lifespan
longevity
mouse

ASJC Scopus subject areas

Ageing
Cell Biology

Access to Document

10.1111/ACEL.12340

Cite this

@article{fd6a25cd867649cca7478d85751af7f9,

title = "The life-extending effect of dietary restriction requires Foxo3 in mice",

abstract = "Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (+/–) and homozygous (–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3+/– or Foxo3–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3+/–, and Foxo3–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3+/– mice contrast with those in Foxo1+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.",

keywords = "Foxo, cancer, dietary restriction, lifespan, longevity, mouse",

author = "Isao Shimokawa and Toshimitsu Komatsu and Nobutaka Hayashi and Kim, {Sang Eun} and Takuya Kawata and Seongjoon Park and Hiroko Hayashi and Haruyoshi Yamaza and Takuya Chiba and Ryoichi Mori",

note = "Funding Information: This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS) (15390128, 16790226, and 20790260) and the JSPS Asian CORE Program. Publisher Copyright: {\textcopyright} 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.",

year = "2015",

month = aug,

doi = "10.1111/ACEL.12340",

language = "English",

volume = "14",

pages = "707--709",

journal = "Aging cell",

issn = "1474-9718",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - The life-extending effect of dietary restriction requires Foxo3 in mice

AU - Shimokawa, Isao

AU - Komatsu, Toshimitsu

AU - Hayashi, Nobutaka

AU - Kim, Sang Eun

AU - Kawata, Takuya

AU - Park, Seongjoon

AU - Hayashi, Hiroko

AU - Yamaza, Haruyoshi

AU - Chiba, Takuya

AU - Mori, Ryoichi

N1 - Funding Information: This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS) (15390128, 16790226, and 20790260) and the JSPS Asian CORE Program. Publisher Copyright: © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

PY - 2015/8

Y1 - 2015/8

N2 - Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (+/–) and homozygous (–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3+/– or Foxo3–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3+/–, and Foxo3–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3+/– mice contrast with those in Foxo1+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.

AB - Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (+/–) and homozygous (–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3+/– or Foxo3–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3+/–, and Foxo3–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3+/– mice contrast with those in Foxo1+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.

KW - Foxo

KW - cancer

KW - dietary restriction

KW - lifespan

KW - longevity

KW - mouse

UR - http://www.scopus.com/inward/record.url?scp=84943648496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943648496&partnerID=8YFLogxK

U2 - 10.1111/ACEL.12340

DO - 10.1111/ACEL.12340

M3 - Article

C2 - 25808402

AN - SCOPUS:84943648496

SN - 1474-9718

VL - 14

SP - 707

EP - 709

JO - Aging cell

JF - Aging cell

IS - 4

ER -

The life-extending effect of dietary restriction requires Foxo3 in mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this