The multiple sample injector using improved sheath flow to prevent sample dilution

Masaki Kanai; Shingo Ikeda; Junichi Tanaka; Jeung Sang Go; Hiroaki Nakanishi; Shuichi Shoji

doi:10.1016/j.sna.2003.08.014

The multiple sample injector using improved sheath flow to prevent sample dilution

Masaki Kanai^*, Shingo Ikeda, Junichi Tanaka, Jeung Sang Go, Hiroaki Nakanishi, Shuichi Shoji

^*Corresponding author for this work

School of Fundamental Science and Engineering

Research output: Contribution to journal › Conference article › peer-review

11 Citations (Scopus)

Abstract

This paper presents a sheath flow multiple sample injector that realizes concentration-conservative sample injection. Stepwise flow is used to reduce the dilution of the sample reagent. Based on the CFD simulation results, it is estimated that sample reagent is diluted to 94% in a conventional sample injector. With stepwise flow, however, the level of dilution is reduced and the average concentration is estimated to be near 100%. For the experiment evaluation, a sample injector is fabricated and the sample injection using stepwise flow is visualized using a fluorescent measuring system. The accuracy of the injected sample volume and the feasibility of multiple sample injection are evaluated based on the experiment results.

Original language	English
Pages (from-to)	32-36
Number of pages	5
Journal	Sensors and Actuators, A: Physical
Volume	111
Issue number	1
DOIs	https://doi.org/10.1016/j.sna.2003.08.014
Publication status	Published - 2004 Mar 1
Event	Micromechanics Section of Sensors and Actuators, based on - Kyoto, Japan Duration: 2003 Jan 19 → 2003 Jan 23

Keywords

CFD simulation
Sample injector
Sheath flow

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering

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10.1016/j.sna.2003.08.014

Cite this

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title = "The multiple sample injector using improved sheath flow to prevent sample dilution",

abstract = "This paper presents a sheath flow multiple sample injector that realizes concentration-conservative sample injection. Stepwise flow is used to reduce the dilution of the sample reagent. Based on the CFD simulation results, it is estimated that sample reagent is diluted to 94% in a conventional sample injector. With stepwise flow, however, the level of dilution is reduced and the average concentration is estimated to be near 100%. For the experiment evaluation, a sample injector is fabricated and the sample injection using stepwise flow is visualized using a fluorescent measuring system. The accuracy of the injected sample volume and the feasibility of multiple sample injection are evaluated based on the experiment results.",

keywords = "CFD simulation, Sample injector, Sheath flow",

author = "Masaki Kanai and Shingo Ikeda and Junichi Tanaka and Go, {Jeung Sang} and Hiroaki Nakanishi and Shuichi Shoji",

note = "Funding Information: This work was supported by Bio-oriented Technology Research Advancement Institution for Research and Development Program for New Bio-industry Initiatives, Japanese Ministry of Education, Culture Sports, Science & Technology Grant-in-Aid for COE Research, Scientific Research (B) No. 12450167, Scientific Research Priority Area (B) No. 13124209, Japan Society for the Promotion Science Grant-in-Aid for Creative Scientific Research No. 13GS0024 and 21COE “Practical Nano-Chemistry” from MEXT, Japan. ; Micromechanics Section of Sensors and Actuators, based on ; Conference date: 19-01-2003 Through 23-01-2003",

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T1 - The multiple sample injector using improved sheath flow to prevent sample dilution

AU - Kanai, Masaki

AU - Ikeda, Shingo

AU - Tanaka, Junichi

AU - Go, Jeung Sang

AU - Nakanishi, Hiroaki

AU - Shoji, Shuichi

N1 - Funding Information: This work was supported by Bio-oriented Technology Research Advancement Institution for Research and Development Program for New Bio-industry Initiatives, Japanese Ministry of Education, Culture Sports, Science & Technology Grant-in-Aid for COE Research, Scientific Research (B) No. 12450167, Scientific Research Priority Area (B) No. 13124209, Japan Society for the Promotion Science Grant-in-Aid for Creative Scientific Research No. 13GS0024 and 21COE “Practical Nano-Chemistry” from MEXT, Japan.

PY - 2004/3/1

Y1 - 2004/3/1

N2 - This paper presents a sheath flow multiple sample injector that realizes concentration-conservative sample injection. Stepwise flow is used to reduce the dilution of the sample reagent. Based on the CFD simulation results, it is estimated that sample reagent is diluted to 94% in a conventional sample injector. With stepwise flow, however, the level of dilution is reduced and the average concentration is estimated to be near 100%. For the experiment evaluation, a sample injector is fabricated and the sample injection using stepwise flow is visualized using a fluorescent measuring system. The accuracy of the injected sample volume and the feasibility of multiple sample injection are evaluated based on the experiment results.

AB - This paper presents a sheath flow multiple sample injector that realizes concentration-conservative sample injection. Stepwise flow is used to reduce the dilution of the sample reagent. Based on the CFD simulation results, it is estimated that sample reagent is diluted to 94% in a conventional sample injector. With stepwise flow, however, the level of dilution is reduced and the average concentration is estimated to be near 100%. For the experiment evaluation, a sample injector is fabricated and the sample injection using stepwise flow is visualized using a fluorescent measuring system. The accuracy of the injected sample volume and the feasibility of multiple sample injection are evaluated based on the experiment results.

KW - CFD simulation

KW - Sample injector

KW - Sheath flow

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DO - 10.1016/j.sna.2003.08.014

M3 - Conference article

AN - SCOPUS:0442311893

SN - 0924-4247

VL - 111

SP - 32

EP - 36

JO - Sensors and Actuators, A: Physical

JF - Sensors and Actuators, A: Physical

IS - 1

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Y2 - 19 January 2003 through 23 January 2003

ER -

The multiple sample injector using improved sheath flow to prevent sample dilution

Abstract

Keywords

ASJC Scopus subject areas

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