The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices

Shigenobu Shibata; Akiko Shiratsuchi; Shyh Yuh Liou; Showa Ueki

doi:10.1016/0304-3940(84)90371-9

The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices

Shigenobu Shibata^*, Akiko Shiratsuchi, Shyh Yuh Liou, Showa Ueki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The role of calcium ions in maintaining the circadian rhythm of suprachiasmatic nucleus (SCN) neuron activity was investigated using rat hypothalamic slice preparations. In normal Krebs solution, the firing rate of SCN neurons was higher in the light period than in the dark period. In Ca²⁺ -free Krebs solution, SCN neuron activity was low during all periods and did not show diurnal rhythm. These results suggest that the disappearance of circadian rhythmic change of SCN neuron activity in Ca²⁺ -free Krebs solution may be due to the disappearance of synaptic transmission in the SCN.

Original language	English
Pages (from-to)	181-184
Number of pages	4
Journal	Neuroscience Letters
Volume	52
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(84)90371-9
Publication status	Published - 1984 Nov 23
Externally published	Yes

Keywords

calcium ions
circadian rhythm
rat brain slice
single unit activity
suprachiasmatic nucleus
synaptic transmission

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(84)90371-9

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title = "The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices",

abstract = "The role of calcium ions in maintaining the circadian rhythm of suprachiasmatic nucleus (SCN) neuron activity was investigated using rat hypothalamic slice preparations. In normal Krebs solution, the firing rate of SCN neurons was higher in the light period than in the dark period. In Ca2+ -free Krebs solution, SCN neuron activity was low during all periods and did not show diurnal rhythm. These results suggest that the disappearance of circadian rhythmic change of SCN neuron activity in Ca2+ -free Krebs solution may be due to the disappearance of synaptic transmission in the SCN.",

keywords = "calcium ions, circadian rhythm, rat brain slice, single unit activity, suprachiasmatic nucleus, synaptic transmission",

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T1 - The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices

AU - Shibata, Shigenobu

AU - Shiratsuchi, Akiko

AU - Liou, Shyh Yuh

AU - Ueki, Showa

PY - 1984/11/23

Y1 - 1984/11/23

N2 - The role of calcium ions in maintaining the circadian rhythm of suprachiasmatic nucleus (SCN) neuron activity was investigated using rat hypothalamic slice preparations. In normal Krebs solution, the firing rate of SCN neurons was higher in the light period than in the dark period. In Ca2+ -free Krebs solution, SCN neuron activity was low during all periods and did not show diurnal rhythm. These results suggest that the disappearance of circadian rhythmic change of SCN neuron activity in Ca2+ -free Krebs solution may be due to the disappearance of synaptic transmission in the SCN.

AB - The role of calcium ions in maintaining the circadian rhythm of suprachiasmatic nucleus (SCN) neuron activity was investigated using rat hypothalamic slice preparations. In normal Krebs solution, the firing rate of SCN neurons was higher in the light period than in the dark period. In Ca2+ -free Krebs solution, SCN neuron activity was low during all periods and did not show diurnal rhythm. These results suggest that the disappearance of circadian rhythmic change of SCN neuron activity in Ca2+ -free Krebs solution may be due to the disappearance of synaptic transmission in the SCN.

KW - calcium ions

KW - circadian rhythm

KW - rat brain slice

KW - single unit activity

KW - suprachiasmatic nucleus

KW - synaptic transmission

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The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices

Abstract

Keywords

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