The role of diastolic pump flow in centrifugal blood pump hemodynamics

Takehide Akimoto*, Kenneth N. Litwak, Kenji Yamazaki, Philip Litwak, Shin Ichiro Kihara, Osamu Tagusari, Shun Ich Yamazaki, Marina V. Kameneva, Mary J. Watach, Mitsuo Umezu, Jun Tomioka, Robert L. Kormos, Hitoshi Koyanagi, Bartley P. Griffith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We tried to verify the hypothesis that increases in pump flow during diastole are matched by decreases in left ventricular (LV) output during systole. A calf (80 kg) was implanted with an implantable centrifugal blood pump (EVAHEART, SunMedical Technology Research Corp., Nagano, Japan) with left ventricle to aorta (LV-Ao) bypass, and parameters were recorded at different pump speeds under general anesthesia. Pump inflow and outflow pressure, arterial pressure, systemic and pulmonary blood flow, and electrocardiogram (ECG) were recorded on the computer every 5 ms. All parameters were separated into systolic and diastolic components and analyzed. The pulmonary flow was the same as the systemic flow during the study (p > 0.1). Systemic flow consisted of pump flow and LV output through the aortic valve. The ratio of systolic pump flow to pulmonary flow (51.3%) did not change significantly at variable pump speeds (p > 0.1). The other portions of the systemic flow were shared by the left ventricular output and the pump flow during diastole. When pump flow increased during diastole, there was a corresponding decrease in the LV output (Y = -1.068X + 51.462; R∧2 = 0.9501). These show that pump diastolic flow may regulate expansion of the left ventricle in diastole.

Original languageEnglish
Pages (from-to)724-727
Number of pages4
JournalArtificial Organs
Issue number9
Publication statusPublished - 2001
Externally publishedYes


  • Centrifugal blood pump
  • Diastolic pump flow
  • Hemodynamics
  • Left ventricular assist device
  • Real-time analysis

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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