TY - JOUR
T1 - The role of exercise in brain DNA damage
AU - Vilela, Thais
AU - De Andrade, Vanessa
AU - Radak, Zsolt
AU - De Pinho, Ricardo
N1 - Funding Information:
Acknowledgments: We thank the National Counsel of Technological and Scientific Development-CNPq/Brazil, Coordination for the Improvement of Higher Education Personnel-CAPES/Brazil, and Research Fund of the Pontifícia Universidade Católica do Paraná for contributing to research activities. Author contributions: TCV, VMA, ZR and RAP contributed to literature searching and the manuscript writing. All authors have read and approved the final version of the manuscript, and agree with the order of presentation of the authors. Conflicts of interest: The authors declare no conflicts of interest. Financial support: None. Copyright license agreement: The Copyright License Agreement has been signed by all authors before publication. Plagiarism check: Checked twice by iThenticate. Peer review: Externally peer reviewed. Open access statement: This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Publisher Copyright:
© 2020 Wolters Kluwer Medknow Publications. All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Cells are constantly subjected to cytotoxic and genotoxic insults resulting in the accumulation of unrepaired damaged DNA, which leads to neuronal death. In this way, DNA damage has been implicated in the pathogenesis of neurological disorders, cancer, and aging. Lifestyle factors, such as physical exercise, are neuroprotective and increase brain function by improving cognition, learning, and memory, in addition to regulating the cellular redox milieu. Several mechanisms are associated with the effects of exercise in the brain, such as reduced production of oxidants, up-regulation of antioxidant capacity, and a consequent decrease in nuclear DNA damage. Furthermore, physical exercise is a potential strategy for further DNA damage repair. However, the neuroplasticity molecules that respond to different aspects of physical exercise remain unknown. In this review, we discuss the influence of exercise on DNA damage and adjacent mechanisms in the brain. We discuss the results of several studies that focus on the effects of physical exercise on brain DNA damage.
AB - Cells are constantly subjected to cytotoxic and genotoxic insults resulting in the accumulation of unrepaired damaged DNA, which leads to neuronal death. In this way, DNA damage has been implicated in the pathogenesis of neurological disorders, cancer, and aging. Lifestyle factors, such as physical exercise, are neuroprotective and increase brain function by improving cognition, learning, and memory, in addition to regulating the cellular redox milieu. Several mechanisms are associated with the effects of exercise in the brain, such as reduced production of oxidants, up-regulation of antioxidant capacity, and a consequent decrease in nuclear DNA damage. Furthermore, physical exercise is a potential strategy for further DNA damage repair. However, the neuroplasticity molecules that respond to different aspects of physical exercise remain unknown. In this review, we discuss the influence of exercise on DNA damage and adjacent mechanisms in the brain. We discuss the results of several studies that focus on the effects of physical exercise on brain DNA damage.
KW - DNA damage
KW - DNA repair
KW - aerobic exercise
KW - apoptosis
KW - brain
KW - brain-derived neurotrophic factor
KW - neurodegenerative disease
KW - oxidative stress
KW - physical exercise
KW - strength exercise
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U2 - 10.4103/1673-5374.282237
DO - 10.4103/1673-5374.282237
M3 - Review article
AN - SCOPUS:85086360425
SN - 1673-5374
VL - 15
SP - 1981
EP - 1985
JO - Neural Regeneration Research
JF - Neural Regeneration Research
IS - 11
ER -