The Role of Reactive Oxygen and Nitrogen Species in Skeletal Muscle

Zsolt Radak*, Erika Koltai

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Skeletal muscle is a very dynamic tissue with a large adaptive capacity and a remarkable resistance to reactive oxygen and nitrogen species (RONS). The reason for this resistance could be the fact that muscle contraction generates RONS, which, up to a certain extent, facilitate the power of contraction. Therefore, moderate levels of RONS appear to be beneficial to muscle function and fiber type differentiation via redox sensitive SIRT1 pathways through MyD and PGC1-alpha. Physiological levels of RONS are likely among those factors which play a role in mitochondrial biogenesis, and the unique subpopulation of mitochondria of skeletal muscle could be differentially affected by RONS. RONS are active, physiological stimulators of certain cellular processes in the skeletal muscle, which include the capacity of force generation, differentiation, and mitochondrial biogenesis. They are also involved in the regulation of antioxidant and oxidative damage-repair systems.

Original languageEnglish
Title of host publicationMuscle and Exercise Physiology
Number of pages7
ISBN (Electronic)9780128145944
ISBN (Print)9780128145937
Publication statusPublished - 2018 Nov 8
Externally publishedYes


  • Antioxidant damage-repair systems
  • Mitochondrial biogenesis
  • Muscle function
  • Oxidative damage-repair systems
  • Reactive oxygen and nitrogen species (RONS)
  • Skeletal muscle

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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