The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma; Zoltan Gombos; Matyas Jokai; Istvan Berkes; Masaki Takeda; Tatsuya Mimura; Zsolt Radak; Ferenc Gyori

doi:10.1016/j.jshs.2020.03.004

The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma, Zoltan Gombos, Matyas Jokai, Istvan Berkes, Masaki Takeda, Tatsuya Mimura, Zsolt Radak^*, Ferenc Gyori

^*Corresponding author for this work

Graduate School of Sport Sciences

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

Original language	English
Pages (from-to)	405-414
Number of pages	10
Journal	Journal of Sport and Health Science
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/j.jshs.2020.03.004
Publication status	Published - 2020 Sept

Keywords

Adaptation
Exercise
MicroRNA
Oxidative damage
Reactive oxygen species
Redox regulation

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1016/j.jshs.2020.03.004

Cite this

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title = "The roles of microRNA in redox metabolism and exercise-mediated adaptation",

abstract = "MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.",

keywords = "Adaptation, Exercise, MicroRNA, Oxidative damage, Reactive oxygen species, Redox regulation",

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AU - Torma, Ferenc

AU - Gombos, Zoltan

AU - Jokai, Matyas

AU - Berkes, Istvan

AU - Takeda, Masaki

AU - Mimura, Tatsuya

AU - Radak, Zsolt

AU - Gyori, Ferenc

PY - 2020/9

Y1 - 2020/9

N2 - MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

AB - MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

KW - Adaptation

KW - Exercise

KW - MicroRNA

KW - Oxidative damage

KW - Reactive oxygen species

KW - Redox regulation

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The roles of microRNA in redox metabolism and exercise-mediated adaptation

Abstract

Keywords

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