The Tokyo Twin Cohort Project: Overview and initial findings

Juko Ando*, Koichi Nonaka, Koken Ozaki, Naho Sato, Keiko K. Fujisawa, Kunitake Suzuki, Shinji Yamagata, Yusuke Takahashi, Ryoko Nakajima, Noriko Kato, Syuichi Ooki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


The Tokyo Twin Cohort Project (ToTCoP) is a large-scale longitudinal study of 5 years based on 1619 pairs of infant twins reared together. The purpose of the study is to construct a population-based twin registry in Japan and to investigate human growth and development and twin themselves. It covers behavioral, neurological, physical and environmental variables measured by questionnaire, home visiting and brain imaging technology. The full registry contains over 47,000 multiple births collected from the Basic Resident Register, and the targeted population is 3070 probable twins of 0 to 2 years old. Preliminary analysis of the entry questionnaire data showed no serious sampling biases. Descriptive statistics of parental characteristics (parental age, gestation age, parity and placentation, maternal weight, parenting stress) and children's characteristics (body size at birth, 4 and 10 months of age, milk consumption, and sleeping and social behavior) and their correlations, genetic and environmental contributions and correlations are reported.

Original languageEnglish
Pages (from-to)817-826
Number of pages10
JournalTwin Research and Human Genetics
Issue number6
Publication statusPublished - 2006 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health


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