The ventromedial nucleus of the hypothalamus outputs long-lasting running in rats

T. Yokawa; D. Mitsushima; C. Itoh; H. Konishi; K. Shiota; M. Takahashi

doi:10.1016/0031-9384(89)90356-9

The ventromedial nucleus of the hypothalamus outputs long-lasting running in rats

T. Yokawa^*, D. Mitsushima, C. Itoh, H. Konishi, K. Shiota, M. Takahashi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We have developed a new technique for altering neural construction by implanting self-swelling, the hydrogel of water-absorbent polymer (WAPGEL) into restricted areas of the brain. Using this technique, we found that the VMH is responsible for expression of running activity. Implantation of 1.5 μl of WAPGEL into the dorsomedial portion of the ventromedial nucleus of the hypothalamus (VMH) of the rat specifically induced bursts of running, whereas implantation into other sites of hypothalamus, e.g., the anterior, lateral and posterior areas, and the dorsomedial nucleus, caused no significant running activity. The WAPGEL-injected rat showed less aversive reactions than the sham-operated rat. Since deafferentation of the VMH after WAPGEL injection prevented the induction of running activity, the output from the VMH appeared to be responsible for the running activity.

Original language	English
Pages (from-to)	713-717
Number of pages	5
Journal	Physiology and Behavior
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/0031-9384(89)90356-9
Publication status	Published - 1989
Externally published	Yes

Keywords

Behavior
Locomotor activity
Running activity
Ventromedial nucleus of the hypothalamus

ASJC Scopus subject areas

Physiology (medical)
Behavioral Neuroscience

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10.1016/0031-9384(89)90356-9

Cite this

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title = "The ventromedial nucleus of the hypothalamus outputs long-lasting running in rats",

abstract = "We have developed a new technique for altering neural construction by implanting self-swelling, the hydrogel of water-absorbent polymer (WAPGEL) into restricted areas of the brain. Using this technique, we found that the VMH is responsible for expression of running activity. Implantation of 1.5 μl of WAPGEL into the dorsomedial portion of the ventromedial nucleus of the hypothalamus (VMH) of the rat specifically induced bursts of running, whereas implantation into other sites of hypothalamus, e.g., the anterior, lateral and posterior areas, and the dorsomedial nucleus, caused no significant running activity. The WAPGEL-injected rat showed less aversive reactions than the sham-operated rat. Since deafferentation of the VMH after WAPGEL injection prevented the induction of running activity, the output from the VMH appeared to be responsible for the running activity.",

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author = "T. Yokawa and D. Mitsushima and C. Itoh and H. Konishi and K. Shiota and M. Takahashi",

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T1 - The ventromedial nucleus of the hypothalamus outputs long-lasting running in rats

AU - Yokawa, T.

AU - Mitsushima, D.

AU - Itoh, C.

AU - Konishi, H.

AU - Shiota, K.

AU - Takahashi, M.

PY - 1989

Y1 - 1989

N2 - We have developed a new technique for altering neural construction by implanting self-swelling, the hydrogel of water-absorbent polymer (WAPGEL) into restricted areas of the brain. Using this technique, we found that the VMH is responsible for expression of running activity. Implantation of 1.5 μl of WAPGEL into the dorsomedial portion of the ventromedial nucleus of the hypothalamus (VMH) of the rat specifically induced bursts of running, whereas implantation into other sites of hypothalamus, e.g., the anterior, lateral and posterior areas, and the dorsomedial nucleus, caused no significant running activity. The WAPGEL-injected rat showed less aversive reactions than the sham-operated rat. Since deafferentation of the VMH after WAPGEL injection prevented the induction of running activity, the output from the VMH appeared to be responsible for the running activity.

AB - We have developed a new technique for altering neural construction by implanting self-swelling, the hydrogel of water-absorbent polymer (WAPGEL) into restricted areas of the brain. Using this technique, we found that the VMH is responsible for expression of running activity. Implantation of 1.5 μl of WAPGEL into the dorsomedial portion of the ventromedial nucleus of the hypothalamus (VMH) of the rat specifically induced bursts of running, whereas implantation into other sites of hypothalamus, e.g., the anterior, lateral and posterior areas, and the dorsomedial nucleus, caused no significant running activity. The WAPGEL-injected rat showed less aversive reactions than the sham-operated rat. Since deafferentation of the VMH after WAPGEL injection prevented the induction of running activity, the output from the VMH appeared to be responsible for the running activity.

KW - Behavior

KW - Locomotor activity

KW - Running activity

KW - Ventromedial nucleus of the hypothalamus

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JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 4

ER -

The ventromedial nucleus of the hypothalamus outputs long-lasting running in rats

Abstract

Keywords

ASJC Scopus subject areas

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