TY - JOUR
T1 - Theta oscillation in the human anterior cingulate cortex during all-night sleep
T2 - An electrocorticographic study
AU - Nishida, Masaki
AU - Hirai, Nobuhide
AU - Miwakeichi, Fumikazu
AU - Maehara, Taketoshi
AU - Kawai, Kensuke
AU - Shimizu, Hiroyuki
AU - Uchida, Sunao
N1 - Funding Information:
This study was supported by the Research Fund from Tokyo Ikashika Daigaku Seishinkai no Kai. We are grateful to Dr. Toru Nishikawa and Dr. Michio Toru for their kind advice and encouragement throughout the entire study process.
PY - 2004/11
Y1 - 2004/11
N2 - Ten epileptic patients each with subdural electrodes surgically attached to the anterior cingulate cortex (ACC; two cases), the orbitofrontal cortex (OFC; seven cases), or both (one case) were included in this study. We recorded each patient's ACC or OFC electrocorticogram (ECoG) during the time period that the patient was awake and naturally asleep. We performed a Fast Fourier Transformation (FFT) power spectral analysis on each ECoG to examine its frequency component. We found that the ACC showed regular and continuous theta oscillation (5-7Hz) during wakefulness and rapid eye movement (REM) sleep, but not during slow wave sleep. Theta waves observed in REM sleep were not as distinct as those found in wakefulness. We also discovered that the orbitofrontal signals represented spectral peaks in the theta band only during wakefulness. This suggests the coexistence of theta oscillation in the ACC. Considering our previous observations of gamma and beta oscillations in the human hippocampus, we hypothesize that the human limbic system manifests two oscillatory activities. The results obtained in this study suggest that electrophysiological activity in the ACC could be related to particular psychological functions in wakefulness and in REM sleep. These results are useful in elucidating the human brain mechanism.
AB - Ten epileptic patients each with subdural electrodes surgically attached to the anterior cingulate cortex (ACC; two cases), the orbitofrontal cortex (OFC; seven cases), or both (one case) were included in this study. We recorded each patient's ACC or OFC electrocorticogram (ECoG) during the time period that the patient was awake and naturally asleep. We performed a Fast Fourier Transformation (FFT) power spectral analysis on each ECoG to examine its frequency component. We found that the ACC showed regular and continuous theta oscillation (5-7Hz) during wakefulness and rapid eye movement (REM) sleep, but not during slow wave sleep. Theta waves observed in REM sleep were not as distinct as those found in wakefulness. We also discovered that the orbitofrontal signals represented spectral peaks in the theta band only during wakefulness. This suggests the coexistence of theta oscillation in the ACC. Considering our previous observations of gamma and beta oscillations in the human hippocampus, we hypothesize that the human limbic system manifests two oscillatory activities. The results obtained in this study suggest that electrophysiological activity in the ACC could be related to particular psychological functions in wakefulness and in REM sleep. These results are useful in elucidating the human brain mechanism.
KW - Anterior cingulate cortex
KW - Electrocorticogram
KW - Human
KW - REM sleep
KW - Theta oscillation
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U2 - 10.1016/j.neures.2004.08.004
DO - 10.1016/j.neures.2004.08.004
M3 - Article
C2 - 15488296
AN - SCOPUS:5644253165
SN - 0168-0102
VL - 50
SP - 331
EP - 341
JO - Neuroscience Research
JF - Neuroscience Research
IS - 3
ER -