Three-dimensional analysis of small airway with X-ray micro-CT

Toshihiro Sera; Yuji Hasegawa; Robert C. Schroter; Kazuo Tanishita

Three-dimensional analysis of small airway with X-ray micro-CT

Toshihiro Sera^*, Yuji Hasegawa, Robert C. Schroter, Kazuo Tanishita

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

To identify the anatomy of small airways, we visualized and quantified the excised rat lung at varying lung volume using the microfocus X-ray CT. We insufflated tantalum dust as contrast agent. Lung volume was varied in steps from functional residual capacity (FRC: 2 mL) to the maximal lung capacity (MLC: 12 mL). At FRC we found out airway closure in small airways (Maximum lumen area was 0.06 mm ² at MLC), where the bronchial walls are held in apposition. Lumen area dramatically varied at the first step during inflation and deflation, and the maximum area at MLC was 8 times as large as the minimum area at FRV.

Original language	English
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Editors	R.D. Kamm, G.W. Schmid-Schoenbein, G.A. Atesian, M.S. Hefzy
Pages	461-462
Number of pages	2
Volume	50
Publication status	Published - 2001
Externally published	Yes
Event	Proceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States Duration: 2001 Jun 27 → 2001 Jul 1

Other

Other	Proceedings of the 2001 Bioengineering Conference
Country/Territory	United States
City	Snowbird, UT
Period	01/6/27 → 01/7/1

ASJC Scopus subject areas

Engineering(all)

Cite this

Three-dimensional analysis of small airway with X-ray micro-CT. / Sera, Toshihiro; Hasegawa, Yuji; Schroter, Robert C. et al.
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. ed. / R.D. Kamm; G.W. Schmid-Schoenbein; G.A. Atesian; M.S. Hefzy. Vol. 50 2001. p. 461-462.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sera, T, Hasegawa, Y, Schroter, RC & Tanishita, K 2001, Three-dimensional analysis of small airway with X-ray micro-CT. in RD Kamm, GW Schmid-Schoenbein, GA Atesian & MS Hefzy (eds), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 50, pp. 461-462, Proceedings of the 2001 Bioengineering Conference, Snowbird, UT, United States, 01/6/27.

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abstract = "To identify the anatomy of small airways, we visualized and quantified the excised rat lung at varying lung volume using the microfocus X-ray CT. We insufflated tantalum dust as contrast agent. Lung volume was varied in steps from functional residual capacity (FRC: 2 mL) to the maximal lung capacity (MLC: 12 mL). At FRC we found out airway closure in small airways (Maximum lumen area was 0.06 mm 2 at MLC), where the bronchial walls are held in apposition. Lumen area dramatically varied at the first step during inflation and deflation, and the maximum area at MLC was 8 times as large as the minimum area at FRV. ",

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AU - Sera, Toshihiro

AU - Hasegawa, Yuji

AU - Schroter, Robert C.

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Y1 - 2001

N2 - To identify the anatomy of small airways, we visualized and quantified the excised rat lung at varying lung volume using the microfocus X-ray CT. We insufflated tantalum dust as contrast agent. Lung volume was varied in steps from functional residual capacity (FRC: 2 mL) to the maximal lung capacity (MLC: 12 mL). At FRC we found out airway closure in small airways (Maximum lumen area was 0.06 mm 2 at MLC), where the bronchial walls are held in apposition. Lumen area dramatically varied at the first step during inflation and deflation, and the maximum area at MLC was 8 times as large as the minimum area at FRV.

AB - To identify the anatomy of small airways, we visualized and quantified the excised rat lung at varying lung volume using the microfocus X-ray CT. We insufflated tantalum dust as contrast agent. Lung volume was varied in steps from functional residual capacity (FRC: 2 mL) to the maximal lung capacity (MLC: 12 mL). At FRC we found out airway closure in small airways (Maximum lumen area was 0.06 mm 2 at MLC), where the bronchial walls are held in apposition. Lumen area dramatically varied at the first step during inflation and deflation, and the maximum area at MLC was 8 times as large as the minimum area at FRV.

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EP - 462

BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

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A2 - Schmid-Schoenbein, G.W.

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T2 - Proceedings of the 2001 Bioengineering Conference

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ER -

Three-dimensional analysis of small airway with X-ray micro-CT

Abstract

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ASJC Scopus subject areas

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