Three-dimensional analysis of small airway with X-ray micro-CT

Toshihiro Sera*, Yuji Hasegawa, Robert C. Schroter, Kazuo Tanishita

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution


To identify the anatomy of small airways, we visualized and quantified the excised rat lung at varying lung volume using the microfocus X-ray CT. We insufflated tantalum dust as contrast agent. Lung volume was varied in steps from functional residual capacity (FRC: 2 mL) to the maximal lung capacity (MLC: 12 mL). At FRC we found out airway closure in small airways (Maximum lumen area was 0.06 mm 2 at MLC), where the bronchial walls are held in apposition. Lumen area dramatically varied at the first step during inflation and deflation, and the maximum area at MLC was 8 times as large as the minimum area at FRV.

Original languageEnglish
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
EditorsR.D. Kamm, G.W. Schmid-Schoenbein, G.A. Atesian, M.S. Hefzy
Number of pages2
Publication statusPublished - 2001
Externally publishedYes
EventProceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States
Duration: 2001 Jun 272001 Jul 1


OtherProceedings of the 2001 Bioengineering Conference
Country/TerritoryUnited States
CitySnowbird, UT

ASJC Scopus subject areas

  • Engineering(all)


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