@inproceedings{5eae16fb6c394f28b9caf6b10d9bd31f,
title = "Three-dimensional pathological analysis of cerebral aneurysm initiation",
abstract = "Cerebral aneurysm is known to initiate at the cerebral artery bifurcation. The pathological mechanism of cerebral aneurysm awaits further understanding especially on its initiation. This study sought to elucidate the three-dimensional structure of cerebral vascular bifurcations with and without aneurysms using human cadavers. The two cases had aneurysmal initiations out of total 7 cases. The studied structure was intimal hyperplasia, tunica media and internal elastic lamina, which were recognized by elastica masson staining. The results showed that the non-existence of tunica media and internal elastic lamina was found in the lesion without aneurysm. The non-existence of intimal hyperplasia was only found in the lesion with aneurysm. These data suggest that the formation of intimal hyperplasia may be related with the initiation of aneurysm. We regarded the boundary of existence arteriosclerosis as the position for new arteriosclerosis occurs and thought the direction of new arteriosclerosis grows would influence whether the cerebral aneurysm initiates or not.",
keywords = "Cerebral aneurysm, Initiation, Internal elastic lamina, Intimal hyperplasia, Tunica media",
author = "Xinning Wang and Kenta Suto and Takanobu Yagi and Koichi Kawamura and Mitsuo Umezu",
note = "Funding Information: Acknowledgements. This work was mainly supported by a research project at Waseda Research Institute for Science and Engineering, Project No.: #13L02, Title: Biomedical Engineering Research for Advanced Medical Treatment Using Nonclinical Study. Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2017.; International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017 ; Conference date: 22-09-2017 Through 24-09-2017",
year = "2017",
doi = "10.1007/978-981-10-6370-1_10",
language = "English",
isbn = "9789811063695",
series = "Communications in Computer and Information Science",
publisher = "Springer Verlag",
pages = "95--103",
editor = "Minrui Fei and Shiwei Ma and Xin Li and Xin Sun and Li Jia and Zhou Su",
booktitle = "Advanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings",
}