Three recent breakthroughs in molecular motor research: recombinant myosin, monomolecular in vitro motility assay and atomic structure of S1

Taro Q.P. Uyeda

doi:10.1016/0928-4931(94)90022-1

Three recent breakthroughs in molecular motor research: recombinant myosin, monomolecular in vitro motility assay and atomic structure of S1

Taro Q.P. Uyeda^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Muscle contraction results from ATP-dependent sliding between actin filaments and S1 domain of myosin, but its molecular mechanism of chemomechanical energy transformation is still elusive despite decades of extensive research. There were three major breakthroughs in this field during the last few years, however; recombinant myosin technology, monomolecular in vitro motility assay, and atomic structure of S1. This article briefly reviews what is currently under dispute in this field, and introduces how molecular biologists, with these new tools in hand, are approaching those questions.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Materials Science and Engineering C
Volume	2
Issue number	1-2
DOIs	https://doi.org/10.1016/0928-4931(94)90022-1
Publication status	Published - 1994 Dec
Externally published	Yes

Keywords

Atomic structure
Motor research
Myosin

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/0928-4931(94)90022-1

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AB - Muscle contraction results from ATP-dependent sliding between actin filaments and S1 domain of myosin, but its molecular mechanism of chemomechanical energy transformation is still elusive despite decades of extensive research. There were three major breakthroughs in this field during the last few years, however; recombinant myosin technology, monomolecular in vitro motility assay, and atomic structure of S1. This article briefly reviews what is currently under dispute in this field, and introduces how molecular biologists, with these new tools in hand, are approaching those questions.

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KW - Myosin

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Three recent breakthroughs in molecular motor research: recombinant myosin, monomolecular in vitro motility assay and atomic structure of S1

Abstract

Keywords

ASJC Scopus subject areas

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