Takashi Kato*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Thrombopoietin is a prime and physiologic regulator of megakaryopoiesis (megakaryocytopoiesis) and platelet production. A glycoprotein binds to its receptor MPL (c-Mpl or TPO receptor) on the surface of megakaryocyte progenitors to stimulate proliferation and differentiation toward mature megakaryocytes with a higher ploidy class that acquires the capacity for platelet shedding, and maintains hematopoietic stem cells. It is predominantly produced in the liver constitutively and in the bone marrow microenvironment inductively. Other nonhematopoietic roles such as antiapoptotic effects in various cells are reported.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
Number of pages5
ISBN (Electronic)9780128206492
Publication statusPublished - 2021 Jan 1


  • Cytokine
  • Hematopoiesis
  • Hematopoietic growth factors
  • Hematopoietic stem cells
  • MPL
  • Megakaryocytes
  • Platelets
  • Thrombopoiesis

ASJC Scopus subject areas

  • Medicine(all)


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