TY - JOUR
T1 - Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy
AU - Yamagishi, Kento
AU - Kirino, Izumi
AU - Takahashi, Isao
AU - Amano, Hizuru
AU - Takeoka, Shinji
AU - Morimoto, Yuji
AU - Fujie, Toshinori
N1 - Funding Information:
This work was supported by the Leading Graduate Program in Science and Engineering, Waseda University from MEXT, Top Global University Program, Waseda University from MEXT, JSPS KAKENHI (grant numbers 15H05355, 15K15503 and 17K20116), a Grant-in-Aid for JSPS Fellows (grant number 16J07140), a Precursory Research for Embryonic Science and Technology (PRESTO) grant from the Japan Science and Technology Agency (JPMJPR152A), the Noguchi Institute and the Tanaka Memorial Foundation. The authors thank K. Iwasaki and X. Zhu (Waseda University) for valuable technical advice and X-ray transmission imaging observations; H. Miyazaki, D. Saitoh (National Defense Medical College), M. Kitajima (Waseda University) and F. Greco (Graz University of Technology) for valuable discussions; and W. Kayukawa, Y. Matsushita and T. Takee for technical assistance in cell culture.
Publisher Copyright:
© 2018, The Author(s).
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Metronomic (that is, low-dose and long-term) photodynamic therapy (mPDT) for treating internal lesions requires the stable fixation of optical devices to internal tissue surfaces to enable continuous, local light delivery. Surgical suturing—the standard choice for device fixation—can be unsuitable in the presence of surrounding major nerves and blood vessels, as well as for organs or tissues that are fragile, change their shape or actively move. Here, we show that an implantable and wirelessly powered mPDT device consisting of near-field-communication-based light-emitting-diode chips and bioadhesive and stretchable polydopamine-modified poly(dimethylsiloxane) nanosheets can be stably fixed onto the inner surface of animal tissue. When implanted subcutaneously in mice with intradermally transplanted tumours, the device led to significant antitumour effects by irradiating for 10 d at approximately 1,000-fold lower intensity than conventional PDT approaches. The mPDT device might facilitate treatment strategies for hard-to-detect microtumours and deeply located lesions that are hard to reach with standard phototherapy.
AB - Metronomic (that is, low-dose and long-term) photodynamic therapy (mPDT) for treating internal lesions requires the stable fixation of optical devices to internal tissue surfaces to enable continuous, local light delivery. Surgical suturing—the standard choice for device fixation—can be unsuitable in the presence of surrounding major nerves and blood vessels, as well as for organs or tissues that are fragile, change their shape or actively move. Here, we show that an implantable and wirelessly powered mPDT device consisting of near-field-communication-based light-emitting-diode chips and bioadhesive and stretchable polydopamine-modified poly(dimethylsiloxane) nanosheets can be stably fixed onto the inner surface of animal tissue. When implanted subcutaneously in mice with intradermally transplanted tumours, the device led to significant antitumour effects by irradiating for 10 d at approximately 1,000-fold lower intensity than conventional PDT approaches. The mPDT device might facilitate treatment strategies for hard-to-detect microtumours and deeply located lesions that are hard to reach with standard phototherapy.
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U2 - 10.1038/s41551-018-0261-7
DO - 10.1038/s41551-018-0261-7
M3 - Article
C2 - 30932063
AN - SCOPUS:85049995912
SN - 2157-846X
VL - 3
SP - 27
EP - 36
JO - Nature Biomedical Engineering
JF - Nature Biomedical Engineering
IS - 1
ER -