@article{09f7e3e633d144dea773a0dc9d9f0fcc,
title = "Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues",
abstract = "Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.",
keywords = "biological evaluations, kakeromamide A, marine cyclopeptide, structural analogs, total synthesis",
author = "Meng Zhao and Yi Xiao and Satoshi Otsuka and Yoichi Nakao and Yian Guo and Tao Ye",
note = "Funding Information: This work was inspired by the international and interdisciplinary environments of the JSPS Asian CORE Program, Asian Chemical Biology Initiative. Funding. We acknowledge financial support from the National Natural Science Foundation of China (21772009, 21901013), the Shenzhen Peacock Plan (KQTD2015071714043444), the Shenzhen Science and Technology Innovation Commission (JCYJ20170818090238288), the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions (2019SHIBS0004). Funding Information: We acknowledge financial support from the National Natural Science Foundation of China (21772009, 21901013), the Shenzhen Peacock Plan (KQTD2015071714043444), the Shenzhen Science and Technology Innovation Commission (JCYJ20170818090238288), the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions (2019SHIBS0004). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Zhao, Xiao, Otsuka, Nakao, Guo and Ye.",
year = "2020",
month = may,
day = "13",
doi = "10.3389/fchem.2020.00410",
language = "English",
volume = "8",
journal = "Frontiers in Chemistry",
issn = "2296-2646",
publisher = "Frontiers Media S. A.",
}
