Total synthesis of (+)-epoxyquinols A and B

Mitsuru Shoji, Junichiro Yamaguchi, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


A highly stereoselective HfCl4-mediated Diels-Alder reaction of furan and the chiral acrylate ester of Corey's auxiliary to subsequently give 1, and the realization of the postulated biosynthetic pathway for the construction of epoxyquinols A and B, namely, oxidative 6π electrocyclization, followed by Diels-Alder reaction of the unprotected monomer are the key steps in the asymmetric total synthesis of (+)-epoxyquinols A and B.

Original languageEnglish
Pages (from-to)3192-3194
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number17
Publication statusPublished - 2002 Sept 2
Externally publishedYes


  • Asymmetric synthesis
  • Diels-Alder reaction
  • Dimerization
  • Epoxyquinol
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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