Total synthesis of palau'amine

Ian B. Seiple, Shun Su, Ian S. Young, Chad A. Lewis, Junichiro Yamaguchi, Phil S. Baran

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)


(Figure Presented) Worth the wait: The long anticipated total synthesis of palau'amine has been accomplished by a route featuring highly chemoselective transformations, cascade reactions, and a remarkable transannular cyclization to secure the unprecedented trans-5,5 ring junction (shown in red).

Original languageEnglish
Pages (from-to)1095-1098
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number6
Publication statusPublished - 2010 Feb 1
Externally publishedYes


  • Axinellamines
  • Massadine
  • Palau'amine
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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