Total synthesis of PDIM A

Tatsuya Nakamura, Hanae Nakagome, Shoichiro Sano, Tomoko Sadayuki, Seijiro Hosokawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

Original languageEnglish
Pages (from-to)550-551
Number of pages2
JournalChemistry Letters
Volume45
Issue number5
DOIs
Publication statusPublished - 2016

Keywords

  • Phthiocerol dimycocerosate A (PDIM A)
  • Total synthesis
  • Tuberculosis

ASJC Scopus subject areas

  • General Chemistry

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