Total synthesis of PDIM A

Tatsuya Nakamura, Hanae Nakagome, Shoichiro Sano, Tomoko Sadayuki, Seijiro Hosokawa*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)


    Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

    Original languageEnglish
    Pages (from-to)550-551
    Number of pages2
    JournalChemistry Letters
    Issue number5
    Publication statusPublished - 2016


    • Phthiocerol dimycocerosate A (PDIM A)
    • Total synthesis
    • Tuberculosis

    ASJC Scopus subject areas

    • Chemistry(all)


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