Total synthesis of PDIM A

Tatsuya Nakamura; Hanae Nakagome; Shoichiro Sano; Tomoko Sadayuki; Seijiro Hosokawa

doi:10.1246/cl.160152

Total synthesis of PDIM A

Tatsuya Nakamura, Hanae Nakagome, Shoichiro Sano, Tomoko Sadayuki, Seijiro Hosokawa^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

Original language	English
Pages (from-to)	550-551
Number of pages	2
Journal	Chemistry Letters
Volume	45
Issue number	5
DOIs	https://doi.org/10.1246/cl.160152
Publication status	Published - 2016

Keywords

Phthiocerol dimycocerosate A (PDIM A)
Total synthesis
Tuberculosis

ASJC Scopus subject areas

Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1246/cl.160152

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title = "Total synthesis of PDIM A",

abstract = "Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.",

keywords = "Phthiocerol dimycocerosate A (PDIM A), Total synthesis, Tuberculosis",

author = "Tatsuya Nakamura and Hanae Nakagome and Shoichiro Sano and Tomoko Sadayuki and Seijiro Hosokawa",

year = "2016",

doi = "10.1246/cl.160152",

language = "English",

volume = "45",

pages = "550--551",

journal = "Chemistry Letters",

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publisher = "Chemical Society of Japan",

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T1 - Total synthesis of PDIM A

AU - Nakamura, Tatsuya

AU - Nakagome, Hanae

AU - Sano, Shoichiro

AU - Sadayuki, Tomoko

AU - Hosokawa, Seijiro

PY - 2016

Y1 - 2016

N2 - Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

AB - Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

KW - Phthiocerol dimycocerosate A (PDIM A)

KW - Total synthesis

KW - Tuberculosis

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DO - 10.1246/cl.160152

M3 - Article

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SP - 550

EP - 551

JO - Chemistry Letters

JF - Chemistry Letters

IS - 5

ER -

Total synthesis of PDIM A

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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