Abstract
Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.
Original language | English |
---|---|
Pages (from-to) | 550-551 |
Number of pages | 2 |
Journal | Chemistry Letters |
Volume | 45 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2016 |
Keywords
- Phthiocerol dimycocerosate A (PDIM A)
- Total synthesis
- Tuberculosis
ASJC Scopus subject areas
- General Chemistry