Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment

Kazuo Nagasawa; Isao Shimizu; Tadashi Nakata

doi:10.1016/0040-4039(96)01503-1

Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment

Kazuo Nagasawa, Isao Shimizu, Tadashi Nakata^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The C11-C23 segment of preswinholide A was stereoselectively synthesized based on the iterative construction of 1,3-polyol chains using a series of sequential reactions which involves the Sharpless asymmetric epoxidation of allyl alcohol and Pd-catalyzed hydrogenolysis of alkenyl oxirane with HCOOH as the key reactions.

Original language	English
Pages (from-to)	6881-6884
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	38
DOIs	https://doi.org/10.1016/0040-4039(96)01503-1
Publication status	Published - 1996 Sept 16

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/0040-4039(96)01503-1

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title = "Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment",

abstract = "The C11-C23 segment of preswinholide A was stereoselectively synthesized based on the iterative construction of 1,3-polyol chains using a series of sequential reactions which involves the Sharpless asymmetric epoxidation of allyl alcohol and Pd-catalyzed hydrogenolysis of alkenyl oxirane with HCOOH as the key reactions.",

author = "Kazuo Nagasawa and Isao Shimizu and Tadashi Nakata",

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AU - Nagasawa, Kazuo

AU - Shimizu, Isao

AU - Nakata, Tadashi

PY - 1996/9/16

Y1 - 1996/9/16

N2 - The C11-C23 segment of preswinholide A was stereoselectively synthesized based on the iterative construction of 1,3-polyol chains using a series of sequential reactions which involves the Sharpless asymmetric epoxidation of allyl alcohol and Pd-catalyzed hydrogenolysis of alkenyl oxirane with HCOOH as the key reactions.

AB - The C11-C23 segment of preswinholide A was stereoselectively synthesized based on the iterative construction of 1,3-polyol chains using a series of sequential reactions which involves the Sharpless asymmetric epoxidation of allyl alcohol and Pd-catalyzed hydrogenolysis of alkenyl oxirane with HCOOH as the key reactions.

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Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment

Abstract

ASJC Scopus subject areas

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