TY - JOUR
T1 - Transient increase in systemic interferences in the superficial layer and its influence on event-related motor tasks
T2 - A functional near-infrared spectroscopy study
AU - Nambu, Isao
AU - Ozawa, Takuya
AU - Sato, Takanori
AU - Aihara, Takatsugu
AU - Fujiwara, Yusuke
AU - Otaka, Yohei
AU - Osu, Rieko
AU - Izawa, Jun
AU - Wada, Yasuhiro
N1 - Publisher Copyright:
© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Functional near-infrared spectroscopy (fNIRS) is a widely utilized neuroimaging tool in fundamental neuroscience research and clinical investigation. Previous research has revealed that task-evoked systemic artifacts mainly originating from the superficial-tissue may preclude the identification of cerebral activation during a given task. We examined the influence of such artifacts on event-related brain activity during a brisk squeezing movement. We estimated task-evoked superficial-tissue hemodynamics from short source-detector distance channels (15 mm) by applying principal component analysis. The estimated superficial-tissue hemodynamics exhibited temporal profiles similar to the canonical cerebral hemodynamic model. Importantly, this task-evoked profile was also observed in data from a block design motor experiment, suggesting a transient increase in superficial-tissue hemodynamics occurs following motor behavior, irrespective of task design. We also confirmed that estimation of event-related cerebral hemodynamics was improved by a simple superficial-tissue hemodynamic artifact removal process using 15-mm short distance channels, compared to the results when no artifact removal was applied. Thus, our results elucidate task design-independent characteristics of superficial- tissue hemodynamics and highlight the need for the application of superficial-tissue hemodynamic artifact removal methods when analyzing fNIRS data obtained during event-related motor tasks.
AB - Functional near-infrared spectroscopy (fNIRS) is a widely utilized neuroimaging tool in fundamental neuroscience research and clinical investigation. Previous research has revealed that task-evoked systemic artifacts mainly originating from the superficial-tissue may preclude the identification of cerebral activation during a given task. We examined the influence of such artifacts on event-related brain activity during a brisk squeezing movement. We estimated task-evoked superficial-tissue hemodynamics from short source-detector distance channels (15 mm) by applying principal component analysis. The estimated superficial-tissue hemodynamics exhibited temporal profiles similar to the canonical cerebral hemodynamic model. Importantly, this task-evoked profile was also observed in data from a block design motor experiment, suggesting a transient increase in superficial-tissue hemodynamics occurs following motor behavior, irrespective of task design. We also confirmed that estimation of event-related cerebral hemodynamics was improved by a simple superficial-tissue hemodynamic artifact removal process using 15-mm short distance channels, compared to the results when no artifact removal was applied. Thus, our results elucidate task design-independent characteristics of superficial- tissue hemodynamics and highlight the need for the application of superficial-tissue hemodynamic artifact removal methods when analyzing fNIRS data obtained during event-related motor tasks.
KW - artifact removal
KW - event-related design
KW - functional near-infrared spectroscopy
KW - general linear model
KW - superficial-tissue hemodynamics
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U2 - 10.1117/1.JBO.22.3.035008
DO - 10.1117/1.JBO.22.3.035008
M3 - Article
C2 - 28294282
AN - SCOPUS:85015785977
SN - 1083-3668
VL - 22
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 3
M1 - 035008
ER -