TY - JOUR
T1 - Tubular Network Formation by Mixing Amphiphilic Polypeptides with Differing Hydrophilic Blocks
AU - Rahman, Md Mofizur
AU - Ueda, Motoki
AU - Son, Kon
AU - Seo, Siyoong
AU - Takeoka, Shinji
AU - Hirose, Takuji
AU - Ito, Yoshihiro
N1 - Funding Information:
This work was financially supported by the Japan Society for the Promotion of Science, a Grant-in-Aid for Scientific Research (S) from KAKENHI 22220009, a Grant-in-Aid for Scientific Research (A) from KAKENHI 15H01810, and a Grant-in-Aid for Early-Career Scientists from KAKENHI 18K15334. TEM measurements were supported by the Materials Characterization Support Unit, RIKEN CEMS. We thank the Edanz Group ( www.edanzediting.com/ac ) for editing a draft of this manuscript.
Publisher Copyright:
Copyright © 2019 American Chemical Society.
PY - 2019/10/14
Y1 - 2019/10/14
N2 - Artificial tubular networks are promising structures for biomaterial applications because of their large surface areas. A tubular network was formed by co-assembling two different amphiphilic polypeptides, poly(ethylene glycol)-b-(l-Leu-Aib)6 (PL12) and polysarcosine-b-(l-Leu-Aib)6 (SL12). They both have the same hydrophobic 12-mer helical block (l-Leu-Aib)6 but different hydrophilic chains, poly(ethylene glycol) and polysarcosine. In water, both polypeptides self-assembled into a tubular structure having a uniform 80 nm diameter that was formed by packing among the hydrophobic L12 blocks. The SL12 nanotubes were short (200 nm), straight, and robust. PL12 formed long (>1 μm), bendable, and fusogenic nanotubes. The amphiphiles were then co-assembled with various mixing ratios to form tubular networks. Higher concentrations of PL12 made the nanotubes more bendable and fusogenic between open tube ends, which produced branching junctions under heat treatment.
AB - Artificial tubular networks are promising structures for biomaterial applications because of their large surface areas. A tubular network was formed by co-assembling two different amphiphilic polypeptides, poly(ethylene glycol)-b-(l-Leu-Aib)6 (PL12) and polysarcosine-b-(l-Leu-Aib)6 (SL12). They both have the same hydrophobic 12-mer helical block (l-Leu-Aib)6 but different hydrophilic chains, poly(ethylene glycol) and polysarcosine. In water, both polypeptides self-assembled into a tubular structure having a uniform 80 nm diameter that was formed by packing among the hydrophobic L12 blocks. The SL12 nanotubes were short (200 nm), straight, and robust. PL12 formed long (>1 μm), bendable, and fusogenic nanotubes. The amphiphiles were then co-assembled with various mixing ratios to form tubular networks. Higher concentrations of PL12 made the nanotubes more bendable and fusogenic between open tube ends, which produced branching junctions under heat treatment.
UR - http://www.scopus.com/inward/record.url?scp=85073104549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073104549&partnerID=8YFLogxK
U2 - 10.1021/acs.biomac.9b00986
DO - 10.1021/acs.biomac.9b00986
M3 - Article
C2 - 31532187
AN - SCOPUS:85073104549
SN - 1525-7797
VL - 20
SP - 3908
EP - 3914
JO - Biomacromolecules
JF - Biomacromolecules
IS - 10
ER -