Ultrasensitive detection of biomolecules using functionalized multi-walled carbon nanotubes

Ping An Hu; Takashi Tanii; Guo Jun Zhang; Takumi Hosaka; Iwao Ohdomari

doi:10.1016/j.snb.2006.12.025

Ultrasensitive detection of biomolecules using functionalized multi-walled carbon nanotubes

Ping An Hu^*, Takashi Tanii, Guo Jun Zhang, Takumi Hosaka, Iwao Ohdomari

^*Corresponding author for this work

School of Fundamental Science and Engineering

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

An ultrasensitive and facile bioassay approach is developed using biofunctional multi-walled carbon nanotubes (MWNTs). The biofunctional MWNTs are exploited to detect trace protein in the homogeneous solution using fluorescent detection. The effect of target concentration on the fluorescent intensity is systematically studied, revealing that the detected signal is strengthened with increase in target concentration. The homogenous target-capture process performed on the biofunctional MWNTs enhances the detection sensitivity largely. The detection limit of 100 pg/ml is achieved through this bioassay.

Original language	English
Pages (from-to)	161-166
Number of pages	6
Journal	Sensors and Actuators, B: Chemical
Volume	124
Issue number	1
DOIs	https://doi.org/10.1016/j.snb.2006.12.025
Publication status	Published - 2007 Jun 10

Keywords

Biomolecules
Carbon nanotubes
Detection

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2006.12.025

Cite this

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abstract = "An ultrasensitive and facile bioassay approach is developed using biofunctional multi-walled carbon nanotubes (MWNTs). The biofunctional MWNTs are exploited to detect trace protein in the homogeneous solution using fluorescent detection. The effect of target concentration on the fluorescent intensity is systematically studied, revealing that the detected signal is strengthened with increase in target concentration. The homogenous target-capture process performed on the biofunctional MWNTs enhances the detection sensitivity largely. The detection limit of 100 pg/ml is achieved through this bioassay.",

keywords = "Biomolecules, Carbon nanotubes, Detection",

author = "Hu, {Ping An} and Takashi Tanii and Zhang, {Guo Jun} and Takumi Hosaka and Iwao Ohdomari",

note = "Funding Information: The authors gratefully acknowledge financial supports from Japan Society for the Promotion of Science (JSPS), and a Grant-in-Aid for Center of Excellence (COE) Research from the Ministry of Education, Culture, Sports, Science and Technology. ",

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AU - Hu, Ping An

AU - Tanii, Takashi

AU - Zhang, Guo Jun

AU - Hosaka, Takumi

AU - Ohdomari, Iwao

N1 - Funding Information: The authors gratefully acknowledge financial supports from Japan Society for the Promotion of Science (JSPS), and a Grant-in-Aid for Center of Excellence (COE) Research from the Ministry of Education, Culture, Sports, Science and Technology.

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Ultrasensitive detection of biomolecules using functionalized multi-walled carbon nanotubes

Abstract

Keywords

ASJC Scopus subject areas

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