Ultrasonic study of 5H-dibenz[B,F]azepine-5-carboxamide and 7-chloro-1,5-dihydro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione

S. Ravi; S. Indira; V. Natchimuthu; C. Sengottaiyan

Ultrasonic study of 5H-dibenz[B,F]azepine-5-carboxamide and 7-chloro-1,5-dihydro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione

S. Ravi^*, S. Indira, V. Natchimuthu, C. Sengottaiyan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The experimental ultrasonic velocity has been measured for anticonvulsants such as Carbamazepine(CBZ), Oxycarbazepine(OXYCBZ) and Clobazam. The drugs are some of the most preferred for almost any kind of seizure. The highly non-soluble nature of such drugs in water might have not encouraged people to estimate the speed of sound through these drugs. In the present paper, based on the solubility of these drugs in DMSO (dimethylsulphoxide), water is gradually added to obtain different concentrations. The sound velocity is measured using 1 and 3 MHz interferometer specifically at room temperature. The sound velocity data is used to estimate the structural parameter which in turn exposes the similarity in behaviour of all the three drugs.

Original language	English
Pages (from-to)	241-244
Number of pages	4
Journal	Indian Journal of Pure and Applied Physics
Volume	51
Issue number	4
Publication status	Published - 2013 Apr
Externally published	Yes

Keywords

Carbamazepine
Clobazam
Structure factor
Ultrasonic velocity

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

Cite this

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title = "Ultrasonic study of 5H-dibenz[B,F]azepine-5-carboxamide and 7-chloro-1,5-dihydro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione",

abstract = "The experimental ultrasonic velocity has been measured for anticonvulsants such as Carbamazepine(CBZ), Oxycarbazepine(OXYCBZ) and Clobazam. The drugs are some of the most preferred for almost any kind of seizure. The highly non-soluble nature of such drugs in water might have not encouraged people to estimate the speed of sound through these drugs. In the present paper, based on the solubility of these drugs in DMSO (dimethylsulphoxide), water is gradually added to obtain different concentrations. The sound velocity is measured using 1 and 3 MHz interferometer specifically at room temperature. The sound velocity data is used to estimate the structural parameter which in turn exposes the similarity in behaviour of all the three drugs.",

keywords = "Carbamazepine, Clobazam, Structure factor, Ultrasonic velocity",

author = "S. Ravi and S. Indira and V. Natchimuthu and C. Sengottaiyan",

year = "2013",

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language = "English",

volume = "51",

pages = "241--244",

journal = "Indian Journal of Pure and Applied Physics",

issn = "0019-5596",

publisher = "National Institute of Science Communication and Information Resources (NISCAIR)",

number = "4",

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T1 - Ultrasonic study of 5H-dibenz[B,F]azepine-5-carboxamide and 7-chloro-1,5-dihydro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione

AU - Ravi, S.

AU - Indira, S.

AU - Natchimuthu, V.

AU - Sengottaiyan, C.

PY - 2013/4

Y1 - 2013/4

N2 - The experimental ultrasonic velocity has been measured for anticonvulsants such as Carbamazepine(CBZ), Oxycarbazepine(OXYCBZ) and Clobazam. The drugs are some of the most preferred for almost any kind of seizure. The highly non-soluble nature of such drugs in water might have not encouraged people to estimate the speed of sound through these drugs. In the present paper, based on the solubility of these drugs in DMSO (dimethylsulphoxide), water is gradually added to obtain different concentrations. The sound velocity is measured using 1 and 3 MHz interferometer specifically at room temperature. The sound velocity data is used to estimate the structural parameter which in turn exposes the similarity in behaviour of all the three drugs.

AB - The experimental ultrasonic velocity has been measured for anticonvulsants such as Carbamazepine(CBZ), Oxycarbazepine(OXYCBZ) and Clobazam. The drugs are some of the most preferred for almost any kind of seizure. The highly non-soluble nature of such drugs in water might have not encouraged people to estimate the speed of sound through these drugs. In the present paper, based on the solubility of these drugs in DMSO (dimethylsulphoxide), water is gradually added to obtain different concentrations. The sound velocity is measured using 1 and 3 MHz interferometer specifically at room temperature. The sound velocity data is used to estimate the structural parameter which in turn exposes the similarity in behaviour of all the three drugs.

KW - Carbamazepine

KW - Clobazam

KW - Structure factor

KW - Ultrasonic velocity

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M3 - Article

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Ultrasonic study of 5H-dibenz[B,F]azepine-5-carboxamide and 7-chloro-1,5-dihydro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione

Abstract

Keywords

ASJC Scopus subject areas

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