TY - JOUR
T1 - Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
AU - Kibe, Ryoko
AU - Kurihara, Shin
AU - Sakai, Yumi
AU - Suzuki, Hideyuki
AU - Ooga, Takushi
AU - Sawaki, Emiko
AU - Muramatsu, Koji
AU - Nakamura, Atsuo
AU - Yamashita, Ayano
AU - Kitada, Yusuke
AU - Kakeyama, Masaki
AU - Benno, Yoshimi
AU - Matsumoto, Mitsuharu
N1 - Funding Information:
This study was supported by the Program for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry by the Bio-oriented Technology Research Advancement Institution (BRAIN), Japan. We thank and Mr. Takuho Kuroda, Mr. Ryo Fujii, Mr. Hiroyuki Harashima, Mr. Takeshi Saeki, Dr. Kuruto Hara, Mr. Taito Yamada, Mr. Hiroaki Ozaki, Mr. Satoshi Kanakubo, and Mr. Takahiro Seto (Kyodo Milk Industry Co. Ltd.) for the providing of fecal samples and Ms. Manami Kondo for the management of control diet test (Kyodo Milk Industry Co. Ltd.).
Funding Information:
Supplementary information accompanies this paper at http://www.nature.com/ scientificreports Competing financial interests: This work was supported by the BRAIN, JAPAN. This work was also funded by Kyodo Milk Industry Co. Ltd and Human Metabolome Technologies, Inc. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. E. Sawaki, K. Muramatsu, A. Nakamura, A. Yamashita, Y. Kitada, and M. Matsumoto are employees of Kyodo Milk Industry Co. Ltd. and had a role in study design, data analysis, preparation of the manuscript, and decision to publish the manuscript. T. Ooga is employee of Human Metabolome Technologies, Inc. and had a role in data analysis and decision to publish the manuscript. All of the other authors declare that they have no conflict of interest. How to cite this article: Kibe, R. et al. Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. Sci. Rep. 4, 4548; DOI:10.1038/srep04548 (2014).
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that polyamine concentrations in somatic tissues (including the brain) decrease with increasing age, and polyamine-rich foods enhance longevity in yeast, worms, flies, and mice, and protect flies from age-induced memory impairment. A main source of exogenous polyamines is the intestinal lumen, where they are produced by intestinal bacteria. We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood. Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. This study shows that intake of arginine and LKM512 may prevent aging-dependent declines in QOL via the upregulation of polyamines.
AB - Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that polyamine concentrations in somatic tissues (including the brain) decrease with increasing age, and polyamine-rich foods enhance longevity in yeast, worms, flies, and mice, and protect flies from age-induced memory impairment. A main source of exogenous polyamines is the intestinal lumen, where they are produced by intestinal bacteria. We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood. Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. This study shows that intake of arginine and LKM512 may prevent aging-dependent declines in QOL via the upregulation of polyamines.
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U2 - 10.1038/srep04548
DO - 10.1038/srep04548
M3 - Article
C2 - 24686447
AN - SCOPUS:84897424557
SN - 2045-2322
VL - 4
JO - Scientific reports
JF - Scientific reports
M1 - 4548
ER -