Utilization of myosin and actin bundles for the transport of molecular cargo

Hideyo Takatsuki*, Kevin M. Rice, Shinichi Asano, B. Scott Day, Mizuki Hino, Kazuhiro Oiwa, Ryoki Ishikawa, Yuichi Hiratsuka, Taro Q.P. Uyeda, Kazuhiro Kohama, Eric R. Blough

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F-actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin-propelled filaments, transport molecules across a motor-patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications.

Original languageEnglish
Pages (from-to)452-457
Number of pages6
Issue number3
Publication statusPublished - 2010 Feb 5
Externally publishedYes


  • Actin bundles
  • Cargo transport
  • Fascin
  • Microchannels
  • Myosin

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • General Chemistry
  • General Materials Science


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