Vascular aging and sarcopenia: Interactions with physiological functions during exercise

Naoyuki Hayashi*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Sarcopenia includes reductions in the skeletal muscle mass, which could be related to the circulatory responses to exercise that support the degree of exertion associated with movements, the blood flow supporting the activities of neurons in the central and peripheral nervous systems, and the regulation of temperature, as well as supporting digestion and absorption. Reduced blood flow could be related to the pathological pathways of sarcopenia. Studies have shown that the age-related decline in blood flow reduces the exchange of oxygen, energy sources, metabolites, and heat between blood and cells, thereby aggravating the trophic state in cells. This chapter addresses vascular aging, focusing on the roles of the functions of skeletal muscle and cerebral, ocular, splanchnic, and skin vessels on locomotion and exercise. Sarcopenia could be bidirectionally related to marked impairments in the cardiovascular system resulting from reduced muscle activity.

Original languageEnglish
Title of host publicationSarcopenia
Subtitle of host publicationMolecular Mechanism and Treatment Strategies
Number of pages17
ISBN (Electronic)9780128221464
ISBN (Print)9780128226575
Publication statusPublished - 2021 Jan 1


  • Blood flow
  • Cerebral vessels
  • Exercise
  • Internal organs
  • Ocular vessels
  • Skeletal muscle
  • Skin vessels

ASJC Scopus subject areas

  • Medicine(all)


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