Ventilatory and Cardiovascular Responses to Hypercapnia after 20 Days of Head-Down Bed Rest

Keisho Katayama; Kohei Sato; Hiroshi Akima; Koji Ishida; Toshio Yanagiya; Hiroaki Kanehisa; Hideoki Fukuoka; Tetsuo Fukunaga; Miharu Miyamura

Ventilatory and Cardiovascular Responses to Hypercapnia after 20 Days of Head-Down Bed Rest

Keisho Katayama^*, Kohei Sato, Hiroshi Akima, Koji Ishida, Toshio Yanagiya, Hiroaki Kanehisa, Hideoki Fukuoka, Tetsuo Fukunaga, Miharu Miyamura

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Introduction: Few studies have attempted to investigate the influence of prolonged head-down bed rest (HDBR) on hypercapnic ventilatory chemosensitivity, and there are no data available regarding associated changes in arterial BP and heart rate (HR). The aim of this study was to clarify the influence of prolonged HDBR on ventilatory and cardiovascular responses to hypercapnia. Methods: There were five healthy men who participated in this study. Resting ventilatory and cardiovascular responses to hypercapnia were measured by means of Read's CO₂ rebreathing method 4 d before and on the 19th day of HDBR. Measured variables included systolic and diastolic BP (SBP and DBP, respectively), inspired minute ventilation (V̇I), and end-tidal partial pressure of CO₂ (PETCO₂). Results: Ventilatory response to hyperoxic hypercapnia (ΔV̇I/ΔPETCO₂) decreased significantly on the 19th day of HDBR (1.42 ± 0.65 to 0.90 ± 0.41 L · min^-1 · torr^-1, p < 0.05). On the other hand, SBP, DBP, and HR responses (ΔSBP/ΔPETCO₂, and ΔHR/ΔPETCO₂) were unchanged. Discussion: The results from this study suggest that prolonged HDBR leads to diminished central hypercapnic ventilatory chemosensitivity.

Original language	English
Pages (from-to)	312-316
Number of pages	5
Journal	Aviation Space and Environmental Medicine
Volume	75
Issue number	4 SEC. I
Publication status	Published - 2004 Apr
Externally published	Yes

Keywords

Arterial BP
Heart rate
HR
Hypercapnic ventilatory chemosensitivity
Hypercapnic ventilatory response

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Pollution
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{a74df034e3614492baf588b80adaa449,

title = "Ventilatory and Cardiovascular Responses to Hypercapnia after 20 Days of Head-Down Bed Rest",

abstract = "Introduction: Few studies have attempted to investigate the influence of prolonged head-down bed rest (HDBR) on hypercapnic ventilatory chemosensitivity, and there are no data available regarding associated changes in arterial BP and heart rate (HR). The aim of this study was to clarify the influence of prolonged HDBR on ventilatory and cardiovascular responses to hypercapnia. Methods: There were five healthy men who participated in this study. Resting ventilatory and cardiovascular responses to hypercapnia were measured by means of Read's CO2 rebreathing method 4 d before and on the 19th day of HDBR. Measured variables included systolic and diastolic BP (SBP and DBP, respectively), inspired minute ventilation ({\.V}I), and end-tidal partial pressure of CO2 (PETCO2). Results: Ventilatory response to hyperoxic hypercapnia (Δ{\.V}I/ΔPETCO2) decreased significantly on the 19th day of HDBR (1.42 ± 0.65 to 0.90 ± 0.41 L · min-1 · torr-1, p < 0.05). On the other hand, SBP, DBP, and HR responses (ΔSBP/ΔPETCO2, and ΔHR/ΔPETCO2) were unchanged. Discussion: The results from this study suggest that prolonged HDBR leads to diminished central hypercapnic ventilatory chemosensitivity.",

keywords = "Arterial BP, Heart rate, HR, Hypercapnic ventilatory chemosensitivity, Hypercapnic ventilatory response",

author = "Keisho Katayama and Kohei Sato and Hiroshi Akima and Koji Ishida and Toshio Yanagiya and Hiroaki Kanehisa and Hideoki Fukuoka and Tetsuo Fukunaga and Miharu Miyamura",

year = "2004",

month = apr,

language = "English",

volume = "75",

pages = "312--316",

journal = "Aviation Space and Environmental Medicine",

issn = "0095-6562",

publisher = "Aerospace Medical Association",

number = "4 SEC. I",

}

TY - JOUR

T1 - Ventilatory and Cardiovascular Responses to Hypercapnia after 20 Days of Head-Down Bed Rest

AU - Katayama, Keisho

AU - Sato, Kohei

AU - Akima, Hiroshi

AU - Ishida, Koji

AU - Yanagiya, Toshio

AU - Kanehisa, Hiroaki

AU - Fukuoka, Hideoki

AU - Fukunaga, Tetsuo

AU - Miyamura, Miharu

PY - 2004/4

Y1 - 2004/4

N2 - Introduction: Few studies have attempted to investigate the influence of prolonged head-down bed rest (HDBR) on hypercapnic ventilatory chemosensitivity, and there are no data available regarding associated changes in arterial BP and heart rate (HR). The aim of this study was to clarify the influence of prolonged HDBR on ventilatory and cardiovascular responses to hypercapnia. Methods: There were five healthy men who participated in this study. Resting ventilatory and cardiovascular responses to hypercapnia were measured by means of Read's CO2 rebreathing method 4 d before and on the 19th day of HDBR. Measured variables included systolic and diastolic BP (SBP and DBP, respectively), inspired minute ventilation (V̇I), and end-tidal partial pressure of CO2 (PETCO2). Results: Ventilatory response to hyperoxic hypercapnia (ΔV̇I/ΔPETCO2) decreased significantly on the 19th day of HDBR (1.42 ± 0.65 to 0.90 ± 0.41 L · min-1 · torr-1, p < 0.05). On the other hand, SBP, DBP, and HR responses (ΔSBP/ΔPETCO2, and ΔHR/ΔPETCO2) were unchanged. Discussion: The results from this study suggest that prolonged HDBR leads to diminished central hypercapnic ventilatory chemosensitivity.

AB - Introduction: Few studies have attempted to investigate the influence of prolonged head-down bed rest (HDBR) on hypercapnic ventilatory chemosensitivity, and there are no data available regarding associated changes in arterial BP and heart rate (HR). The aim of this study was to clarify the influence of prolonged HDBR on ventilatory and cardiovascular responses to hypercapnia. Methods: There were five healthy men who participated in this study. Resting ventilatory and cardiovascular responses to hypercapnia were measured by means of Read's CO2 rebreathing method 4 d before and on the 19th day of HDBR. Measured variables included systolic and diastolic BP (SBP and DBP, respectively), inspired minute ventilation (V̇I), and end-tidal partial pressure of CO2 (PETCO2). Results: Ventilatory response to hyperoxic hypercapnia (ΔV̇I/ΔPETCO2) decreased significantly on the 19th day of HDBR (1.42 ± 0.65 to 0.90 ± 0.41 L · min-1 · torr-1, p < 0.05). On the other hand, SBP, DBP, and HR responses (ΔSBP/ΔPETCO2, and ΔHR/ΔPETCO2) were unchanged. Discussion: The results from this study suggest that prolonged HDBR leads to diminished central hypercapnic ventilatory chemosensitivity.

KW - Arterial BP

KW - Heart rate

KW - HR

KW - Hypercapnic ventilatory chemosensitivity

KW - Hypercapnic ventilatory response

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JF - Aviation Space and Environmental Medicine

IS - 4 SEC. I

ER -

Ventilatory and Cardiovascular Responses to Hypercapnia after 20 Days of Head-Down Bed Rest

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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