Violation of the fluctuation-dissipation theorem in a protein system

Kumiko Hayashi*, Mitsunori Takano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


We report the results of molecular dynamics simulations of the protein myosin carried out with an elastic network model. Quenching the system, we observe glassy behavior of a density correlation function and a density response function that are often investigated in structure glasses and spin glasses. In the equilibrium, the fluctuation-response relation, a representative relation of the fluctuation-dissipation theorem, holds that the ratio of the density correlation function to the density response function is equal to the temperature of the environment. We show that, in the quenched system that we study, this relation can be violated. In the case that this relation does not hold, this ratio can be regarded as an effective temperature. We find that this effective temperature of myosin is higher than the temperature of the environment. We discuss the relation between this effective temperature and energy transduction that occurs after ATP hydrolysis in the myosin molecule.

Original languageEnglish
Pages (from-to)895-901
Number of pages7
JournalBiophysical Journal
Issue number3
Publication statusPublished - 2007 Aug

ASJC Scopus subject areas

  • Biophysics


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