17(ß-Hydroxy-16α-[125I]iodowortmannin, a sensitive labeling agent for pi 3-kinases

Shinobu Honzawa; Hiroshi Kurosu; Osamu Hazeki; Toshiaki Katada; Masakatsu Shibasaki; Masahisa Nakada

doi:10.1248/cpb.43.2276

17(ß-Hydroxy-16α-[¹²⁵I]iodowortmannin, a sensitive labeling agent for pi 3-kinases

Shinobu Honzawa, Hiroshi Kurosu, Osamu Hazeki, Toshiaki Katada, Masakatsu Shibasaki^*, Masahisa Nakada

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

To detect phosphatidylinositol (PI) 3-kinases with high sensitivity, we designed and prepared a radiolabeled derivative of wortmannin (1), a potent inhibitor of PI 3-kinases. The synthesized derivative, 17ß-hydroxy-16α-[¹²⁵I]iodowortmannin (7), showed an IC⁵⁰ that was 100-fold higher than that of wortmannin itself and which bound to catalytic subunits of PI 3-kinases.

本文言語	English
ページ（範囲）	2276-2278
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	43
号	12
DOI	https://doi.org/10.1248/cpb.43.2276
出版ステータス	Published - 1995

ASJC Scopus subject areas

化学 (全般)
創薬

文献へのアクセス

10.1248/cpb.43.2276

他のファイルとリンク

引用スタイル

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AU - Katada, Toshiaki

AU - Shibasaki, Masakatsu

AU - Nakada, Masahisa

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