2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture

Julius Adam V. Lopez; Toshihiko Nogawa; Kazuko Yoshida; Yushi Futamura; Hiroyuki Osada

doi:10.1093/bbb/zbab192

2-Methylthio-N⁷-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture

Julius Adam V. Lopez, Toshihiko Nogawa, Kazuko Yoshida, Yushi Futamura, Hiroyuki Osada^*

^*この研究の対応する著者

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

2-Methylthio-N7-methyl-cis-zeatin (1) was isolated from the culture broth of Streptomyces sp. 80H647 along with 2 known purine derivatives, 5′-methylthioinosine (2) and AT-265 (dealanylascamycin, 3). The structure elucidation of compound 1 was accomplished by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analyses. It inhibited the growth of Plasmodium falciparum 3D7 with a GI50 of 2.4 μm and had no effect on the growth of Arabidopsis at 2 μm. This is the first report of an N7-methylated zeatin-type natural product from Streptomyces and as an antimalarial compound.

本文言語	English
ページ（範囲）	31-36
ページ数	6
ジャーナル	Bioscience, Biotechnology and Biochemistry
巻	86
号	1
DOI	https://doi.org/10.1093/bbb/zbab192
出版ステータス	Published - 2022 1月 1
外部発表	はい

ASJC Scopus subject areas

医学（全般）

文献へのアクセス

10.1093/bbb/zbab192

他のファイルとリンク

引用スタイル

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